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Bariatric and Obstructive Lung Disease Study II — BOLD II  

Obesity Clinical Trial

Official title:
Effects of Obesity on Airway Caliber and Airway Smooth Muscle Tone

Clinical Trial Summary

The prevalence of obesity and asthma has significantly increased over the past two decades. The purpose of this study is to try and understand the mechanism by which obesity leads to airway hyperresponsiveness (AHR), one of the defining features of asthma. This research is being done to determine how weight or body size affects airway size and airway smooth muscle (ASM) tone and function. The goal of the study will be to look at if and how, weight might affect lung functioning.

The investigators hypothesize that low lung volumes in obesity lead to AHR by reducing airway caliber causing increased ASM tone with impairment in deep inspiration (DI) response similar to what is seen in asthma.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01127399
Study type Observational
Source Johns Hopkins University
Contact
Status Terminated
Phase N/A
Start date September 2009
Completion date June 2011
View Details
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