Investigation of Cardiac Function and Cardiovascular Risk Factors in Marathon Runners- The Munich Marathon Study

Obesity Clinical Trial

— MMS  

Official title:

Investigation of Myocardial Injury, Ventricular Dysfunction and Cardiovascular Risk Factors in Different Groups of Marathon Runners

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00500773
• Other study ID #: 1807/07
• Status: Completed
• Phase: N/A
• First received: July 11, 2007
• Last updated: April 30, 2014
• Start date: July 2007
• Est. completion date: May 2008

Study information

• Verified date: April 2014
• Source: Technische Universität München
• Contact: n/a
• Is FDA regulated: No
• Health authority: Germany: Ethics Commission
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to determine the cardiovascular risk involved in the exertional exercise of marathon running. The researchers aim to investigate the beneficial effects of regular well-dosed exercise on health and compare these findings with the effects of the extreme strains of marathon running. Subclinical injuries to heart and arteries are being investigated in different groups of runners, including obese participants.

Description:

Regular exercise leads to an improvement of cardiovascular risc factors in patients with coronary heart disease, atherosclerosis and metabolic disorders. Aerobic exercise has anti-inflammatory effects. In contrast, the exertional exercise of marathon running causes an acute pro-inflammatory impulse. This may lead to myocardial injury and, in case of preexisting plaques, may result in plaque rupture and acute myocardial infarction.

The researchers aim to define the critical role of inflammatory markers and cardiovascular risk factors as a predictor of an increased risk for myocardial and endothelial dysfunction in marathon runners.

The study groups are divided into average trained runners (40 km/week), average trained obese runners and highly trained runners (> 70km/week). Training programmes are supervised by professional coaches. Individual scientific marathon contests are organized for the assessments.

Diagnostic tools include measurements of pulse wave velocity and heart rate turbulence, echocardiography and, for the first time, MRI-scans pre- and post marathon running. Additionally, cardiovascular markers such as endothelial progenitor cells (EPCs)and adiponectin are measured. Inflammatory markers include c-reactive protein (CRP), interleukins and tumor necrosis factor.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: May 2008
• Est. primary completion date: March 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 30 Years to 60 Years

Eligibility

Inclusion Criteria:

• Men aged 30-60 years

• Obese subjects: BMI > 27 and waist circumference > 102cm

Exclusion Criteria:

• manifested heart disease

• insulin dependent diabetes mellitus

• multiple drug therapy

• GFR < 60 ml/min.

• claustrophobia

• metal implants

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Microcirculation
• Modes of Exercise and Myocardial and Endothelial Function
• Obesity
• Subclinical Endorgan Damage

Locations

Country	Name	City	State
Germany	Department of Prevention and Sportsmedicine, Technical University of Munich	Connollystrasse 32, Munich	Bavaria

Sponsors (2)

Lead Sponsor	Collaborator
Technische Universität München	Ludwig-Maximilians - University of Munich

Country where clinical trial is conducted

Germany, 

External Links

•   Institutional homepage