Obesity Clinical Trial
Official title:
Influence of Chronobiological and Neuroendocrine Factors in Appetite Regulation and Obesity Treatment
BACKGROUND: Several reports have observed that the alteration of normal biological rhythms is
associated with obesity development. In this regard, those subject with the preference for
evening seems to be prone to develop obesity. However, the current treatment of obesity does
not take into account these aspects OBJECTIVE: To evaluate whether a diet adjusted to
patient's chronotype is more effective than the current dietary recommendations.
SUBJECTS/METHODS: 209 subjects take part in a randomized, double-blind clinical trial. 104
subjects followed a typical hypocaloric dietary treatment (CONTROL) and the other 105
subjects undergone a diet with a daily caloric distribution adjusted to their chronotype
(CHRONO).
CONCLUSIONS: A chronotype-adjusted diet may be a promising alternative to the classical
hypocaloric dietary treatment since the investigator's data indicate a higher effectiveness
regarding weight loss when the diet was adjusted to the patient's chronotype.
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