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Clinical Trial Summary

Obesity is associated with low testosterone in men and with dyslipidemia. Adropin hormone is negatively correlated with body mass index and is associated with dyslipidemia.

correlation between adropin and testosterone will be evaluated.


Clinical Trial Description

Obesity, a worldwide epidemic is associated with multiple adverse health outcome as diabetes mellitus, hypertension and cardiovascular diseases caused mainly by dyslipidemia linked to obesity. Low testosterone levels in obese men were found associated with dyslipidemia.

Adropin is a new metabolic hormone that was first isolated in liver and brain tissues, It was observed that mice fed on a high-fat diet (HFD) had a rapid increase in adropin expression compared to control values. In human also, adropin levels were negatively correlated with body mass index (BMI) and were associated with dyslipidemia.

Adiponectin is a protein that is mainly produced by white adipose tissue and has an important role in lipid metabolism. Serum adiponectin concentrations were decreased in obese compared to normal weight men and significantly correlated with testosterone level. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03724825
Study type Observational
Source Aswan University Hospital
Contact Asmaa Abdelmageed Muhammed, Assistant lecturer
Phone 01098548122
Email asmaa.ali@med.aswu.edu.eg
Status Not yet recruiting
Phase
Start date November 30, 2018
Completion date January 2020

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