Obesity Clinical Trial
Official title:
The Impact of Dietary Sweetness on Neurocognitive Responses to Visual Food Cues, Appetite and Physiological Parameters on Normal Weight Adults: a Pilot Study
This study aims to examine potential differences in neurocognitive responses to food-related cues, physiological and appetite responses as well as subsequent energy intake following the consumption of preloads differing in sweetness and/ or postprandial metabolic effects in healthy normal weight subjects.
Excess consumption of caloric sweeteners, together with the high availability of palatable
food cues are some of the factors for the alarming high rates of overweight and obesity.
Although non-nutritive sweeteners (NNS) are used to decrease energy content of foods and
beverages, there is an on-going debate on the relationship between NNS intake, obesity and
cardiometabolic risk. Caloric sugars have a differing effect on physiological responses
compared to NNS. However it is almost wholly unknown how NNS consumption affects eating
behaviour and cognitive processes.
This study compares the performance on food related neurocognitive tasks following the
consumption of the test preloads on 5 visits. In particular, sucrose, glucose, maltodextrin,
water or a natural high potency sweetener from leaf extract will be ingested as single test
agents in randomized order. Water will be used as a control for gastric distension and
non-sweet, whereas maltodextrin will be used as a non-sweet control for carbohydrate content.
Participants will be asked to attend a screening visit at the Neuroscience and Psychiatry
Unit of the University of Manchester on a morning after overnight fast. Participants' weight
and height, fasting blood glucose and blood pressure will be measured. This will be followed
by some questionnaires regarding general health status, weight and dieting history and eating
behaviour.
Participants who satisfy the inclusion criteria, will be then invited to take part in the
full study. This will require 5 separate visits at the University of Manchester, which will
be scheduled between 11.30 and 13.30. Participants will have to attend these visits after
having fasted for 3-4 hours and will be asked to have their regular breakfast in the morning
before the testing session, and then not eat or drink anything else for 3-4 hours until they
come in the lab for the testing session. Water will be allowed up to 1 hour prior to your
testing session. Prior to each testing session participants will be asked to have the same
breakfast, and they will have to provide a picture of the breakfast each time to ensure
compliance.
The 5 visits correspond to 5 test beverages, both the participants and the investigators are
blinded to the study treatments. Blood will be collected at 0 (before the consumption of the
test beverage), 15, 30 and 60 min after the consumption of the drink. Participants will also
be asked to rate their feeling of hunger, fullness etc using visual analogue scales (VAS) at
the same time points 0, 15, 30 and 60 min.
Fifteen min after the consumption of the drink, participants will complete a set of
computer-based tasks. They are designed to capture behaviour in response to food cue
presentation. This will last approximately 15 min.
Thirty min after the consumption of the drink, a lunch buffet will be served and participants
will be free to eat as much or as little as they like until feeling comfortably full. Each
session is anticipated to last for approximately 1 hour.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04101669 -
EndoBarrier System Pivotal Trial(Rev E v2)
|
N/A | |
Recruiting |
NCT04243317 -
Feasibility of a Sleep Improvement Intervention for Weight Loss and Its Maintenance in Sleep Impaired Obese Adults
|
N/A | |
Terminated |
NCT03772886 -
Reducing Cesarean Delivery Rate in Obese Patients Using the Peanut Ball
|
N/A | |
Completed |
NCT03640442 -
Modified Ramped Position for Intubation of Obese Females.
|
N/A | |
Completed |
NCT04506996 -
Monday-Focused Tailored Rapid Interactive Mobile Messaging for Weight Management 2
|
N/A | |
Recruiting |
NCT06019832 -
Analysis of Stem and Non-Stem Tibial Component
|
N/A | |
Active, not recruiting |
NCT05891834 -
Study of INV-202 in Patients With Obesity and Metabolic Syndrome
|
Phase 2 | |
Active, not recruiting |
NCT05275959 -
Beijing (Peking)---Myopia and Obesity Comorbidity Intervention (BMOCI)
|
N/A | |
Recruiting |
NCT04575194 -
Study of the Cardiometabolic Effects of Obesity Pharmacotherapy
|
Phase 4 | |
Completed |
NCT04513769 -
Nutritious Eating With Soul at Rare Variety Cafe
|
N/A | |
Withdrawn |
NCT03042897 -
Exercise and Diet Intervention in Promoting Weight Loss in Obese Patients With Stage I Endometrial Cancer
|
N/A | |
Completed |
NCT03644524 -
Heat Therapy and Cardiometabolic Health in Obese Women
|
N/A | |
Recruiting |
NCT05917873 -
Metabolic Effects of Four-week Lactate-ketone Ester Supplementation
|
N/A | |
Active, not recruiting |
NCT04353258 -
Research Intervention to Support Healthy Eating and Exercise
|
N/A | |
Completed |
NCT04507867 -
Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III
|
N/A | |
Recruiting |
NCT03227575 -
Effects of Brisk Walking and Regular Intensity Exercise Interventions on Glycemic Control
|
N/A | |
Completed |
NCT01870947 -
Assisted Exercise in Obese Endometrial Cancer Patients
|
N/A | |
Recruiting |
NCT06007404 -
Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
|
||
Recruiting |
NCT05972564 -
The Effect of SGLT2 Inhibition on Adipose Inflammation and Endothelial Function
|
Phase 1/Phase 2 | |
Recruiting |
NCT05371496 -
Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction
|
Phase 2 |