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Obesity clinical trials

View clinical trials related to Obesity.

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NCT ID: NCT04940429 Terminated - Clinical trials for Bariatric Surgery Candidate

Eye Movement Testing in Patients With Obesity and the Impact of Weight Loss Surgery

Start date: November 27, 2018
Phase:
Study type: Observational

Obesity is a condition of chronic low-grade inflammation, thought to be secondary to adipose tissue secretion of cytokines including interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF- α) which effect multiple pathways and lead to an increase in C-reactive protein (CRP), a sensitive marker of systemic inflammation. Chronic inflammation is thought to be a major risk factor for the development of metabolic syndrome, diabetes, cardiovascular disease and cancer. Inflammatory cytokines have also been shown to directly and indirectly interact with the central nervous system influencing behavior and neural activity. Obesity is an independent risk factor for reduced cognitive function including poor attention, executive function and memory. Demonstrating improvement in dynamic visual processing following bariatric surgery could expand our understanding of the impact of obesity on central nervous system (CNS) function.

NCT ID: NCT04801641 Terminated - Obesity Clinical Trials

A Pilot Trial of Nabilone for the Treatment of Obesity

Start date: September 17, 2021
Phase: Phase 2
Study type: Interventional

Obesity is a serious health problem which increases the likelihood of developing other life-changing medical conditions. Despite increasing knowledge about the neural and metabolic basis of obesity, the development of effective anti-obesity treatment strategies has been a challenge. Evidence shows an association between cannabis consumption and body weight. However, to date, no human trials have assessed the potential of cannabis-like compounds to reduce body weight in individuals who are obese. This pilot trial aims to determine the safety and feasibility of administering nabilone (a cannabinoid drug similar to the active component of cannabis) to patients who are obese. Our secondary aims are to determine if nabilone is effective in reducing weight in this population, and to probe potential mechanisms of the weight-loss-promoting effects of nabilone, such as neural reactivity to food stimuli, changes in gut bacteria, and changes in metabolic biomarkers.

NCT ID: NCT04784286 Terminated - Obesity Clinical Trials

Telemedicine Follow-up for Bariatric Surgery Patients: What Do Patients Prefer

Start date: May 14, 2019
Phase: N/A
Study type: Interventional

This is a randomized clinical trial that will randomize bariatric patients undergoing laparoscopic sleeve gastrectomy or laparoscopic Roux-en-Y gastric bypass to receive either in-person or telemedicine post-operative follow-up within 30 days after surgery.

NCT ID: NCT04759989 Terminated - Obesity Clinical Trials

Fluid Resuscitation in Septic Shock Patients With BMI Elevation

FRISSBE
Start date: June 1, 2021
Phase: N/A
Study type: Interventional

To explore the safety and feasibility of alternative fluid resuscitation strategies in obese patients with septic shock.

NCT ID: NCT04741074 Terminated - Obesity Clinical Trials

Effect of Subcutaneous Semaglutide on Kidney Transplant Candidacy

RAISE-KT
Start date: July 23, 2021
Phase: Phase 3
Study type: Interventional

This randomized study evaluates the effect of subcutaneous semaglutide /in combination with lifestyle counseling in patients with type 2 diabetes mellitus (T2DM), overweight/obesity, and stage 4-5 chronic kidney disease (CKD) or dialysis-dependent end-stage kidney disease (ESKD) on patients' eligibility for kidney transplantation at the end of 9 months.

NCT ID: NCT04530617 Terminated - Obesity Clinical Trials

Camostat and Artemisia Annua vs Placebo in COVID-19 Outpatients

Start date: October 5, 2020
Phase: Phase 2
Study type: Interventional

This is a randomized, double-blind, placebo-controlled, multi-arm, multicenter, phase II trial design to allow a rapid efficacy and toxicity assessment of potential therapies (camostat mesilate and artemisia annua) immediately after COVID-19 positive testing in mild to moderate disease and high-risk factors such as diabetes, hypertension, and obesity among others.

NCT ID: NCT04504682 Terminated - Obesity Clinical Trials

Ambulation With Labor Epidural in Obese Women

Start date: August 25, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if ambulation with a labor epidural in place is associated with decreased rate of cesarean delivery in obese patients.

NCT ID: NCT04422951 Terminated - Obesity, Childhood Clinical Trials

Wise Social Psychological Interventions to Improve Outcomes of Behavioral Weight Control in Children With Obesity

Start date: April 6, 2023
Phase: N/A
Study type: Interventional

A 2-arm, parallel group, randomized controlled trial to evaluate overall differences in body mass index (BMI) trajectories over 6 months between 10-16-year-old children with obesity randomized to receive the wise social psychological interventions plus a usual care behavioral intervention for weight management compared to children randomized to receive additional education plus a usual care behavioral intervention.

NCT ID: NCT04417816 Terminated - Obesity Clinical Trials

Ultrasound-induced Adipose Tissue Cavitation and Training in Obesity

UATC
Start date: April 15, 2018
Phase: N/A
Study type: Interventional

The addition of ultrasound-induced adipose tissue cavitation (UATC) at the level of the abdominal subcutaneous adipose tissue may seem relevant as an additive treatment option to exercise intervention in individuals with obesity. However, whether individuals with obesity who participate in an exercise intervention and additionally undergo UATC, are more likely to develop a metabolically healthy phenotype, as opposed to subjects with obesity undergoing exercise training or UATC only, remains to be studied. Therefore, the first aim of this study is to examine the impact of combined UATC during exercise intervention on abdominal subcutaneous and whole-body adipose tissue mass, quality of life and cardiometabolic risk in individuals with abdominal obesity.

NCT ID: NCT04199351 Terminated - Obesity Clinical Trials

Single and Multiple Ascending Dose Study of AMG 171 in Subjects With Obesity

Start date: December 13, 2019
Phase: Phase 1
Study type: Interventional

To assess the safety and tolerability of AMG 171 as single or multiple doses in subjects with obesity