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Clinical Trial Summary

The overarching goal of this project is to determine whether the effect of gut microbiota on human metabolism might be mediated by short chain fatty acids (SCFA) and whether the SCFA might modulate lipid metabolism.

Clinical Trial Description

This would be the first study determining the effect of SCFA synthesis on hepatic de novo lipogenesis and to assess whether and how isocaloric dietary changes (namely low carbohydrates) might modify the composition of the gut microbiota and reduce the synthesis of SCFA during adolescence, a sensitive period for the development of obesity. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT03454828
Study type Interventional
Source Yale University
Contact Nicola Santoro, PhD,MD
Phone 203-737-6356
Status Not yet recruiting
Phase N/A
Start date April 1, 2018
Completion date March 31, 2023

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