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Microbial Basis of Systemic Malodor and "People Allergic To Me" Conditions — PATM  

Nutritional and Metabolic Diseases Clinical Trial

Official title:
Dynamics of the Gut Microbiota in Idiopathic Malodor Production

Clinical Trial Summary

The purpose of this study is to identify microbial signatures associated with remission and recurrence of idiopathic malodor and PATM conditions.

Clinical Trial Description

Human odorprints, mostly owing to the microbiome, have proven their value as biomarkers of health and environmental exposures. In recent years, microbial networks responsible for localized malodors such as halitosis or axillary odor have been mapped by using next generation sequencing approaches. Intestinal microbes responsible for psychologically debilitating systemic malodor (whole-body and extraoral halitosis), however, remain to be identified. Even a relatively straightforward disorder of choline metabolism trimethylaminuria (TMAU) is thought to exhibit complex host-gene microbiome interactions and has not been sufficiently studied. Proposed controlled pilot study aims to explore the dynamics of microbial communities in remission and flare-up periods. Better knowledge of the important aspects of disease fluctuation should enhance patient care and, combined with our prior data, will help to develop new therapies and treatments. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03582826
Study type Interventional
Source Mebo Research, Inc.
Contact
Status Completed
Phase N/A
Start date June 16, 2018
Completion date February 10, 2020
View Details
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