Clinical Trials Logo

Clinical Trial Summary

The aim of the current study is to investigate the postprandial metabolic response to typically consumed fat and carbohydrate doses in single meals. An additional aim is to validate the use of dry blood spot (DBS) for triglyceride analysis versus venous blood sampling.


Clinical Trial Description

Background: Dietary fat consumption is one of the major modifiable risk factors implicated in the causation of cardiovascular disease (CVD). Postprandial lipaemia (PPL); the increase in circulating blood triacylglycerol (TAG) concentrations after a fat containing meal, is an independent risk factor for cardiovascular disease. However, little is known about how different doses of fats as found in typical UK meals will influence the level of PPL.

The majority of research into PPL, including work by our own group and others has largely focused on the postprandial effect following high fat meals, with the primary goal of assessing mechanisms underlying fat metabolism. However, these findings are not relevant from a public health perspective; in reality the average fat content of a meal is much lower than this (~20- 30 g fat, (NDNS, 2013/4)); therefore it is important to assess the impact of doses of fat in this range on PPL to be relevant to public health. The few dose response studies that have been performed assessing fat load and PPL have used liquid test meals that are not relevant to every day meals.

PPL is usually measured by taking a series of blood samples from a cannula, however this is an invasive procedure. There has been an increase in the development of less invasive biochemical assessment, e.g. urine or saliva analysis or dried blood spot (DBS) analysis. DBS analysis is particularly advantageous as samples can be easily collected by the individual under assessment with minimal equipment and transferred easily for analysis via the post, providing simple home-testing. Frequently, postprandial research studies will draw blood from the cannula for multiple related outcomes and therefore, performing multiple assays from one DBS sample would be advantageous in minimizing participant discomfort.

Aim: The primary aim of the current study is to investigate the postprandial response following typical UK meal nutrient profiles containing 20-30g fat. Secondary aims will be to test the feasibility for measuring PPL, insulin, c-peptide and performing metabolomic analysis from DBS versus serum blood analysis. Further, it will assess the best practice for collection (venous versus finger prick) and storage (ambient versus freezer) of the DBS samples.

Hypothesis: Typical UK meal nutrient profiles will elicit detectable PPL. Further, DBS will be an effective method for measuring postprandial outcomes.

Expected value: The study will provide novel information on the effect of fat doses from typical UK meals on PPL. It will also provide feasibility for using DBS for measuring postprandial responses. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03531398
Study type Interventional
Source King's College London
Contact
Status Completed
Phase N/A
Start date April 1, 2018
Completion date September 1, 2018

See also
  Status Clinical Trial Phase
Not yet recruiting NCT05934318 - L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE) N/A
Completed NCT02376530 - Price Changes and Nutrient Profiling Among Adult Grocery Shoppers N/A
Completed NCT01040975 - Teen CHAT: Improving Physician Communication With Adolescents About Healthy Weight N/A
Completed NCT00957814 - Nutritional Orientations and Adherence, Nutritional Status, Clinical and Life Quality Parameters of Heart Failure (HF) Patients N/A
Completed NCT00808756 - Study on Fermentable Carbohydrates in Healthy Infants N/A
Completed NCT03290118 - The Efficacy of Front-of-package Labelling Schemes: an Experimental Study N/A
Active, not recruiting NCT03575884 - Fit 5 Kids Screen Time Reduction Curriculum for Latino Preschoolers N/A
Completed NCT03963778 - Organisational Culture and Nutritional Care
Completed NCT05633251 - Using Reinforcement Schedules to Increase Fruit&Vegetable Intake, Reduce Waste, and Increase School Lunch Participation N/A
Recruiting NCT05138276 - Effect of Autologous Cord Blood Mononuclear Cells for Digestive System in Preterm Neonates Early Phase 1
Completed NCT03906851 - Active and Healthy Kids in Telemark - a School Based Health Promoting Intervention N/A
Not yet recruiting NCT02950779 - Assessment of Handgrip Strength in Adults With Inflammatory Bowel Disease N/A
Completed NCT02486588 - Increasing Engagement With a Healthy Food Benefit N/A
Withdrawn NCT01184027 - Impact of Nutrition and Swallowing Function of Head and Neck Cancer Patients During the Course of Treatment N/A
Completed NCT01178398 - Understanding Fish Consumption Habits During Pregnancy N/A
Completed NCT01249508 - Nutrition Labeling Program to Promote Healthy Dietary Patterns N/A
Terminated NCT00577499 - Effect of Lubiprostone on Nutritional Status and Pulmonary Function in Adults With Cystic Fibrosis N/A
Completed NCT00109551 - Community Trial of Zinc Supplementation on Preschool Child Mortality and Morbidity in Southern Nepal Phase 3
Completed NCT03910426 - Prognostic Determinants of Survival and Quality of Life in Prevalent End-stage Kidney Disease Patients
Recruiting NCT04146870 - Nutritional Status of Patients After Hematopoietic Stem Cell Transplantation