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Clinical Trial Summary

This is a Phase 1/2a, open-label, multi-center study of JAB-3068 in Patients with advanced solid tumors.This study has two phases: dose escalation phase and dose expansion phase.


Clinical Trial Description

Dose escalation study phase is designed to determine the maximum tolerated dose (MTD) according to a 3+3 design and recommended phase II dose (RP2D) and to characterize the safety, tolerability, and pharmacokinetics (PK) profile of JAB-3068. Other dose regimens may be explored based on the analysis of emerging PK and safety data. at this study phase, JAB-3068 dministered orally once daily (QD) or twice daily (BID) or once every other day (QOD) in 28-day treatment cycles to adult patients with advanced solid tumors, Dose expansion study phase is designed to evaluate the antitumor activity(ORR and DOR) of JAB-3068 in patients with NSCLC, ESCC and HNSCC. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03565003
Study type Interventional
Source Jacobio Pharmaceuticals Co., Ltd.
Contact Yuankai Shi, MD
Phone 86 010 87788293
Email syuankaipumc@126.com
Status Recruiting
Phase Phase 1/Phase 2
Start date November 20, 2018
Completion date September 2022

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