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The Feasibility and Clinical Efficacy of Atezolizumab Consolidation Treatment in High Risk (IPI > 2) DLBCL — HO151DLBCL  

NHL Clinical Trial

Official title:
A Phase II Study Evaluating the Feasibility and Clinical Efficacy of Atezolizumab Consolidation Treatment in High Risk Diffuse Large B-cell Lymphoma

NCT number NCT03463057
Study type Interventional
Source Stichting Hemato-Oncologie voor Volwassenen Nederland
Contact M. Nijland, MD
Phone +31 50 3611761
Email m.nijland@umcg.nl
Status Not yet recruiting
Phase Phase 2
Start date April 2018
Completion date April 2025
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Clinical Trial Summary

The prognosis of Diffuse Large B cell Lymphoma (DLBCL) patients with an early relapse is dismal. Atezolizumab has shown promising activity in relapsed DLBCL patients. Toxicity data on atezolizumab are available for > 6000 patients and is manageable. The assumption of this study is that atezolizumab consolidation will result in higher disease free survival by eradicating minimal residual disease In melanoma and lung cancer consolidation immunotherapy after chemoradiotherapy has shown an increase in survival.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
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