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Mechanisms of Disease Severity in Multiple Sclerosis: an Integrative Multimodal Study — SEP-BIO-PROG  

Multiple Sclerosis Clinical Trial

Official title:
Mechanisms of Disease Severity in Multiple Sclerosis: an Integrative Multimodal Study

Clinical Trial Summary

This study will identify a combination of disease severity markers (genetic, immunology, epigenetic, imaging) associated with disease severity and progression in a cohort of patients with multiple sclerosis.

Clinical Trial Description

The heterogeneity of multiple sclerosis evolution relies on several pathophysiological mechanisms including neuroinflammation, neurodegeneration and remyelination and repair mechanisms.

The study will identify markers of disease severity in a longitudinal cohort of patients with multiple sclerosis who are siblings (both siblings having multiple sclerosis) including: biological markers (genetic, immunological and epigenetic markers, advanced MRI markers). An integrative model to predict disease progression will be proposed based on multimodal markers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03369106
Study type Observational
Source Institut National de la Santé Et de la Recherche Médicale, France
Contact Céline Louapre, MD, PhD
Phone +33 1 42 16 57 66
Email celine.louapre@aphp.fr
Status Not yet recruiting
Phase N/A
Start date December 15, 2017
Completion date June 15, 2022
View Details
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