Multiple Sclerosis Clinical Trial
Official title:
Analysis of a Biomarker Signature, Consisting of Toll-like Receptor 2 (TLR2), TLR4 and CCR1, by Flow Cytometry in Patients With MS Treated With Gilenya (FTY720)
This study investigates whether there is a link between disease activity/progression in patients receiving Gilenya and expression of a putative biomarker signature in patients with multiple sclerosis.
Gilenya modulates expression of the sphingosine-1-phosphate receptor and inhibits egress of
several lymphocyte subsets from lymph nodes. This results in immunosuppression that has a
beneficial effect in patients with multiple sclerosis.
Our laboratory reported that increased expression of a possible biomarker signature,
consisting of TLR2, TLR4 and CCR1, in a T-subset is associated with rapid MS progression.
The investigators will test whether a significant proportion of patients at baseline
upregulate this biomarker signature in one or more T-subsets, whether expression of this
biomarker signature changes with treatment with Gilenya and whether expression levels of
this signature predict disease activity or progression over a 12 month followup period. The
investigators will study patients who are already being treated with Gilenya by their
neurologists or who are already being treated with Gilenya as part of a clinical trial
sponsored by Novartis Pharmaceuticals Canada. Patients will not be treated with Gilenya for
the purposes of our study.
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Observational Model: Cohort, Time Perspective: Prospective
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