Multiple Sclerosis, Relapsing-Remitting Clinical Trial
Official title:
Study to Investigate the Immune Response and Safety of Prophylactic Vaccines in Patients Treated for Multiple Sclerosis
The aim of this study is to determine whether prophylactic vaccines recommended are effective and safe in patients with multiple sclerosis(MS) under MS-specific therapy.
Protective vaccines against communicable diseases are of major importance in patients with
autoimmune diseases or impaired immune response. In patients with multiple sclerosis
bacterial or viral infections may lead to disease progression and vaccines can protect from
these infections and prevent disease progression. Fear of possible side effects of vaccines
have led to a general restraint regarding vaccination of patients with MS. However, previous
studies have not shown an increased risk of disease progression following Hepatitis B
vaccination and even a reduced progression rate in relapsing-remitting MS after
tetanus/diphtheria vaccination.
Various disease modifying treatments (DMT) are available for MS, most of these therapies lead
to an impairment of the immune system affecting the immune response to vaccination.
Additionally, live attenuated vaccines may lead to severe side-effects if used in patients
under DMT treatment. Testing immune response after vaccination may be prudent in subjects
undergoing DMT to assure vaccination success since only a limited number of studies have
investigated immune response after vaccination in patients with MS undergoing DMT.
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