Phase I Trial of BCMA-TGF-BETA CAR-T Cells in Relapsed, Refractory Myeloma

Status Not yet recruiting

Clinical Trial Summary

This is a phase I, interventional, single-arm, open-label, dose-finding treatment study designed to evaluate the safety and efficacy of interleukin-7(IL-7) / interleukin-15 (IL-15) manufactured CAR T cells in adult patients with relapsed and/or refractory myeloma that have failed prior therapies.

Clinical Trial Description

BCMA-Transforming growth factor-beta (TGFβ) CAR-T cells will be administered either fresh or thawed after cryopreservation by IV injection. Patients will receive one of three dose levels of BCMA-TGFβ CAR-T cells based on our dose escalation design. After the maximal tolerated dose (MTD) is determined, an additional dose-expansion cohort of up to 9 patients (3 BCMA-naïve and 6 BCMA exposed) may be enrolled at that dose to further describe the safety and preliminary efficacy of that dose. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05976555
Study type	Interventional
Source	Medical College of Wisconsin
Contact	Medical College of Wisconsin Cancer Center Clinical Trials Offic
Phone	866-680-0505
Email	cccto@mcw.edu
Status	Not yet recruiting
Phase	Phase 1
Start date	June 2024
Completion date	May 2028

View Details

See also
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