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Radiotherapy With Immunotherapy for Systemic Effect in Myeloma (RISE-M) — RISE-M  

Multiple Myeloma Clinical Trial

Official title:
Radiotherapy With Immunotherapy for Systemic Effect in Myeloma (RISE-M)

Clinical Trial Summary

Eligible patients have multiple myeloma with measurable disease in the blood and a targetable soft tissue or bony lesion with radiotherapy. All eligible patients will receive immunotherapy (Nivolumab) plus radiotherapy, 6 Gy x 5 fractions, to a targetable lesion. Immunotherapy treatment starts with the first radiotherapy fraction. Nivolumab will be given every 2 weeks. Patients will have specified laboratory values measured bi-monthly and evaluated for response at 12 weeks as defined by International Myeloma Working Group Criteria. Patients will continue to receive their respective immunotherapy until disease progression or dose limiting toxicity is reached.

Clinical Trial Description

All eligible patients will receive immunotherapy (Nivolumab) plus radiotherapy, 6 Gy x 5 fractions, to a targetable lesion. Immunotherapy treatment starts with the first radiotherapy fraction. Nivolumab will be given every 2 weeks. Patients will have specified laboratory values measured bi-monthly and evaluated for response at 12 weeks as defined by International Myeloma Working Group Criteria. Patients will continue to receive their respective immunotherapy until disease progression or dose limiting toxicity is reached. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03634800
Study type Interventional
Source Weill Medical College of Cornell University
Contact
Status Terminated
Phase Phase 2
Start date October 23, 2018
Completion date January 16, 2020
View Details
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