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Clinical Trial Summary

This research study is studying a combination of drugs as a possible treatment for multiple myeloma.

The drugs that will be administered are:

- ABI-009 (nab-rapamycin)

- Pomalidomide

- Dexamethasone


Clinical Trial Description

This research study is a Phase I clinical trial, which tests the safety of an investigational drug and also tries to define the appropriate dose of the investigational drug to use for further studies. "Investigational" means that the drug is being studied.

The FDA (the U.S. Food and Drug Administration) has not approved ABI-009 as a treatment for any disease.

The FDA has approved pomalidomide and dexamethasone as treatment options for multiple myeloma.

The purpose of this study is to determine whether ABI-009 (study drug) will be safe and slow the progress of the disease when used in combination with pomalidomide and dexamethasone, depending on what type of cancer.

ABI-009 is an inhibitor of an overactive biological pathway in the cancer cells. Pomalidomide is an immunomodulatory agent and believed to work by affecting the growth signals that keep cancer cells alive. Dexamethasone is a steroid which is believed to kill cancer cells. The investigators hope that the combination of ABI-009 with pomalidomide and dexamethasone will help stop the growth of the cancer. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03657420
Study type Interventional
Source Massachusetts General Hospital
Contact Andrew J. Yee, MD
Phone 617-724-4000
Email ayee1@mgh.harvard.edu
Status Not yet recruiting
Phase Phase 1
Start date September 30, 2018
Completion date September 30, 2024

See also
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