Multiple Myeloma Clinical Trial
Official title:
A Phase Ib Investigation of the Safety and Efficacy of ABI-009 (Nab-rapamycin) in Combination With Pomalidomide and Dexamethasone for Relapsed and Refractory Multiple Myeloma
This research study is studying a combination of drugs as a possible treatment for multiple
myeloma.
The drugs that will be administered are:
- ABI-009 (nab-rapamycin)
- Pomalidomide
- Dexamethasone
This research study is a Phase I clinical trial, which tests the safety of an investigational
drug and also tries to define the appropriate dose of the investigational drug to use for
further studies. "Investigational" means that the drug is being studied.
The FDA (the U.S. Food and Drug Administration) has not approved ABI-009 as a treatment for
any disease.
The FDA has approved pomalidomide and dexamethasone as treatment options for multiple
myeloma.
The purpose of this study is to determine whether ABI-009 (study drug) will be safe and slow
the progress of the disease when used in combination with pomalidomide and dexamethasone,
depending on what type of cancer.
ABI-009 is an inhibitor of an overactive biological pathway in the cancer cells. Pomalidomide
is an immunomodulatory agent and believed to work by affecting the growth signals that keep
cancer cells alive. Dexamethasone is a steroid which is believed to kill cancer cells. The
investigators hope that the combination of ABI-009 with pomalidomide and dexamethasone will
help stop the growth of the cancer.
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