Multiple Myeloma Clinical Trial
Official title:
Myeloma Treatment in Real Life : Pharmacoepidemiological Approach in Midi-pyrénées
As part of an oral treatment regimen in ambulatory practice, certain uses in connection with
drug consumption associated could alter treatment outcomes observed in randomized clinical
trials.
The increase in progression-free survival in myeloma may be accompanied by an impaired
quality of life and a resurgence of pain symptoms over time, which could potentially lead to
medication overuse involving painkillers but also psychotropic drugs. These combined
consumption may affect survival through mechanisms of pharmacological or non-pharmacological
interactions.
As part of this project, we wish to explore the scheme of adherence to myeloma drugs, and
thus validate the decision diagram of hypothesis of not adequate of drug use in ambulatory
conditions, from observational data. This discrepancy could result from poor adherence or
suboptimal drug use but also from concomitant exposures to other drugs which may interact
with myeloma. Before considering a study of greater magnitude that could address the
consequences of non optimal drug use on clinical response criteria, such as duration of
response or survival, it seems appropriate to confirm these assumptions within ' an
exploratory study.
n/a
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