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Multiple Myeloma clinical trials

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NCT ID: NCT03741127 Enrolling by invitation - Multiple Myeloma Clinical Trials

Long-Term Follow-Up Study for Subjects Treated With P-BCMA-101

Start date: October 29, 2018
Phase: Phase 1
Study type: Interventional

Subjects are enrolled in this study following completion or early discontinuation from a Poseida sponsored or supported study of P-BCMA-101 T cells and will be followed for a total of 15 years post treatment from the last P-BCMA-101 treatment. Subjects will be monitored for safety and efficacy to assess the risk of delayed adverse events (AEs) and assess long-term efficacy, and PK and quantification of P-BCMA-101 T cells. Rimiducid may be administered as indicated.

NCT ID: NCT03628612 Enrolling by invitation - Multiple Myeloma Clinical Trials

Long-term Follow-up of Patients Treated With Autologous T Cells Genetically Modified

Start date: August 3, 2018
Phase: Phase 2
Study type: Interventional

The purpose of this study is to monitor all patients exposed to an existing AUTO CAR T cell therapy, as well as the Sponsor's future autologous T cell products for up to 15 years following their first AUTO CAR T cell therapy infusion.

NCT ID: NCT03619252 Enrolling by invitation - Multiple Myeloma Clinical Trials

Pneumococcal Vaccination of Multiple Myeloma Patients on Novel Agents

Start date: July 1, 2018
Phase: Phase 4
Study type: Interventional

Multiple myeloma is an incurable blood cancer of plasma cells that occurs in older individuals. Novel agents (proteasome inhibitors, immunomodulatory agents) have substantially improved the overall response rates, progression-free survival and overall survival in patients with multiple myeloma. Patients with multiple myeloma are at high risk of developing life-threatening Streptococcus pneumoniae infections, while clinical efficacy and safety of conjugate pneumococcal vaccines in multiple myeloma patients receiving novel agents have not been studied before. The main aim of this study is to assess the clinical efficacy and safety of 13-valent pneumococcal conjugate vaccine in multiple myeloma patients treated with novel agents.

NCT ID: NCT03090659 Enrolling by invitation - Clinical trials for Refractory or Relapsed Multiple Myeloma

LCAR-B38M-02 Cells in Treating Relapsed/Refractory (R/R) Multiple Myeloma

LEGEND-2
Start date: October 2, 2015
Phase: Phase 1/Phase 2
Study type: Interventional

This is a single arm, open-label, multi-center, phase 1/2 study, to determine the safety and efficacy of LCAR-B38M CAR-T cells in treating patients diagnosed with refractory/relapsed multiple myeloma (r/r MM).

NCT ID: NCT02840110 Enrolling by invitation - Multiple Myeloma Clinical Trials

Long-Term Follow-Up Study of Subjects Treated With ACTR T Cell Product

Start date: October 2016
Phase:
Study type: Observational

Subjects treated with an ACTR product may participate in this long-term follow-up study after the completion of the final scheduled visit in the parent clinical study or other investigational setting, such as compassionate use, named patient Investigational New Drug application, expanded access program, or equivalent setting. No investigational product or treatment will be administered in this study. These subjects will be followed for safety monitoring on a schedule of decreasing frequency through 15 years post-ACTR treatment, in accordance with US FDA Regulatory guidance pertaining to long-term safety follow-up for study subjects receiving recombinant DNA-containing investigational products.

NCT ID: NCT02786511 Enrolling by invitation - Multiple Myeloma Clinical Trials

Longterm Follow-up of Subjects Treated With bb2121

Start date: April 28, 2016
Phase:
Study type: Observational

This is a multi-center, non-randomized, open label, longterm safety and efficacy follow-up study for subjects who have been treated with bb2121 in the Phase 1 clinical parent study, that evaluated the safety and efficacy of bb2121 in subjects with relapsed or refractory B cell maturation antigen (BCMA)-expressing multiple myeloma. bb2121 is defined as autologous T lymphocytes (T cells) transduced ex vivo with anti-BCMA02 CAR lentiviral vector encoding the chimeric antigen receptor (CAR) targeted to human BCMA suspended in cryopreservative solution. bb2121 is administered in subjects 1 time (or retreated if retreatment criteria are met) in parent clinical study. No investigational treatment will be administered in this study. After completing the parent study, eligible subjects will be followed for up to 15 years after their last bb2121 infusion in the parent study.

NCT ID: NCT02473757 Enrolling by invitation - Multiple Myeloma Clinical Trials

Gene Therapy Follow-up Protocol for People Previously Enrolled in NCI Experimental Transplantation and Immunology Branch Studies

Start date: September 24, 2015
Phase:
Study type: Observational

Background: - Gene therapy is a way to treat or prevent disease using genes. It is monitored very closely by regulators because there can be long-term, unexpected side effects. NIH is required to try to contact people who have been treated with gene therapy at least annually for up to 15 years. This is to see if they have had any bad side effects. This trial does not include any therapy and is only for patients previously treated on gene-therapy trials at the NCI Experimental Transplantation an Immunology Branch who are no longer enrolled on their original gene therapy clinical trial. Objective: - To collect of long-term follow-up data on people who have been in gene transfer studies. This follow-up is required by regulators. Eligibility: - People age 18 and older who have been in a previous NCI Experimental Transplantation and Immunology Branch gene therapy research study. Design: - After they get the genetically modified cells, participants will: - Have blood drawn 3, 6, and 12 months later. - Have an annual clinic visit for the next 4 years. They will have a physical exam. They will answer questions about any signs of neurological, autoimmune, or blood disorders, or any new cancers. Blood <TAB>may be drawn. - Be called or emailed annually for the next 10 years. They will answer health questions. Blood samples may need to be taken. - Participants will be asked for their current address and phone number. They will also be asked for the address and phone number of 1 or 2 people who will know their whereabouts. One of these should be a family member if possible, - At the time of the participant s death, researchers will request permission from their family for an autopsy.

NCT ID: NCT02298816 Enrolling by invitation - Multiple Myeloma Clinical Trials

B-Cell Hematologic Malignancy Vaccination Registry

HMvax-Regist
Start date: August 2014
Phase:
Study type: Observational [Patient Registry]

The goal of this study is to develop a vaccination registry system for Aurora Health Care patients newly diagnosed with MM and other B-Cell Hematologic Malignancies in order to prospectively characterize vaccination history and outcomes such as infection in these patients at Aurora Health Care. Additionally hospitalization rates, cost analysis, infection (influenza, pneumonia, other) related to vaccination in this patient population will be evaluated.

NCT ID: NCT02024815 Enrolling by invitation - Clinical trials for Multiple Myeloma and Malignant Plasma Cell Neoplasms

Comparable Investigation of One Fraction Radiotherapy and Multifraction Radiotherapy in Patients With Multiple Myeloma.

Start date: September 2011
Phase: Phase 3
Study type: Interventional

Radiotherapy is required to overcome pain and to evoke recalcification in multiple myeloma (MM) patients. Approximately 70% of all MM patients receive one or more radiotherapies in the course of their illness. The relief of pain is obtained in 75 - 100%. Recalcification is achieved in 40 - 50% of the irradiated bone destructions.There were a lot of randomized trials showed the same effect of single (SF) and multiple fractions (MF) in pain relief and recalcification for patients with painful bone metastases from solid tumors. The role of different palliative radiotherapeutic regimens for MM is not well established due to lack of clinical trials. Our prospective study analyzed the effect of two different radiotherapeutic regimens in the treatment of MM on pain relief, analgesics consumption and recalcification.

NCT ID: NCT01421186 Enrolling by invitation - Multiple Myeloma Clinical Trials

A Phase I/IIa Study of Human Anti-CD38 Antibody MOR03087 (MOR202) in Relapsed/Refractory Multiple Myeloma

Start date: July 2011
Phase: Phase 1/Phase 2
Study type: Interventional

This is an open-label, multicentre, dose escalation study to characterize the safety and preliminary efficacy of the human anti-CD38 antibody MOR03087 (MOR202), in adult subjects with relapsed/refractory multiple myeloma, as monotherapy and in adult subjects with relapsed/refractory multiple myeloma in combination with standard therapy.