Sildenafil Citrate in Early Unexplained Recurrent Pregnancy Loss

Status Completed

Clinical Trial Summary

Recurrent unexplained spontaneous miscarriage (RSM) is defined as three consecutive pregnancy loss prior to 20 weeks from the last menstrual period. 1% to 2% of women experience RSM. Treatment of URSM is a challenging issue. The currently available lines of treatment according to simplicity of use, reliability and degree of invasiveness include corticosteroids, sildenafil citrate, aspirin, heparin and immunoglobulins (besides good antenatal care), but up to now there are no prospective randomized studies, powerful enough, to determine a significant difference between these therapeutic protocols, with any of the above mentioned pharmacological agents.

Sildenafil Citrate (Viagra®), a vasodilator, is also described as an anti-inflammatory agent. While improving uterine blood flow in the proliferative phase, NO may have detrimental effects at the level of the endometrium during the implantation window. The NO- mediated release of cytokines such as tumour necrosis factor- from activated natural killer cells has been implicated as a cause of implantation failure.

Based on these observations, this study attempts was made to study uterine arteries and sub-endometrial blood flow during the luteal phase in normal fertile women and in patients with Unexplained recurrent miscarriage

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03766594
Study type	Interventional
Source	Ain Shams University
Contact
Status	Completed
Phase	Phase 1
Start date	January 1, 2018
Completion date	December 1, 2018

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05969574` - Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?
Completed	`NCT00606905` - Intravenous Immunoglobulin (IVIG) for Treatment of Unexplained Secondary Recurrent Miscarriage	N/A
Not yet recruiting	`NCT02706470` - Use of Cyclosporin A for the Treatment of Recurrent Miscarriage	Phase 2/Phase 3
Recruiting	`NCT04709796` - The Use of High Concentration Hyaluronic Acid (HA) Transfer Medium in Repeated Implantation Failure (RIF) Patients	N/A
Not yet recruiting	`NCT00425867` - PAR Family Polymorphisms and Placental Invasion Disorders	N/A
Recruiting	`NCT03009370` - The Effect of the Ovarian Reserve on the Recurrent Pregnancy Loss	N/A
Completed	`NCT05437471` - Effects of Co-treatment on Endometrial abv3-integrin Expressions in Women With Recurrent Implantation Failure	N/A
Completed	`NCT03703401` - The Role of Hydrosalpinx in Recurrent Miscarriage
Completed	`NCT03336463` - Prediction of Recurrent Pregnancy Loss by a New Thrombophilia Based Genetic Risk Score	N/A
Active, not recruiting	`NCT04544462` - ANXA5 M2 Haplotyping in IVF Patients and Embryos
Completed	`NCT04141618` - The Role of NLRP Gene Family (NLRP1~14) in Recurrent Miscarriage and Infertility