Effects of Resisted Versus Balance Exercises on Cognitive And Motor Function In Patients With Mild Cognitive Impairment

Mild Cognitive Impairment Clinical Trial

Official title:

Effects of Resisted Versus Balance Exercises on Cognitive And Motor Function In Patients With Mild Cognitive Impairment

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06308237
• Other study ID #: REC/RCR&AHS/23/0293
• Status: Recruiting
• Phase: N/A
• Start date: February 25, 2024
• Est. completion date: June 25, 2024

Study information

• Verified date: March 2024
• Source: Riphah International University
• Contact: Muhammad Kashif, PhD-PT
• Phone: 03333125303
• Email: kashif.shaffi[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Mild cognitive impairment affects older adults and it includes memory and attentions deficits, and problem-solving difficulties in activities of daily living. Resisted exercises is considered a viable strategy to improve balance and motor function in older population. Balance exercises comprises proprioceptive, visual and motor learning to a larger degree and has positive effects on memory and spatial cognition and improves balance and motor function. This study aims to determine the effects of resisted and balance exercises on cognition and motor function in patients with mild cognitive impairment.

Description:

This randomized clinical trial will be conducted at Aziz Bhatti Shaheed Teaching Hospital Gujrat in seven months after approval of synopsis. The sample size for this trial is 78 patients with MCI. The participants will be randomly allocated into two groups using Online Randomization tool. Group A will receive resisted exercises for 30 minutes and Group B will receive balance exercises for 30 minutes. Participants will receive 3 sessions on alternate days per week for 12 weeks.Montreal Cognitive Assessment (MoCA) and Computerized battery test will be used to assess cognitive impairment, Mini-besTest and Time Up and Go Test (TUG) for balance and motor function.Data will be entered and analysed by using SPSS 26 software.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 66
• Est. completion date: June 25, 2024
• Est. primary completion date: June 20, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 60 Years to 75 Years

Eligibility

Inclusion Criteria:

1. Patients with Mild Cognitive Impairment. (Having score between 18 - 24) on MoCA.

2. Participants with Both Genders will be included .

3. The Age limit for the participants will be 60 to 75 years.

4. Patients having Independence of life (ability to walk independently without any walking aid).

Exclusion Criteria:

1. Previous and current History Cardiovascular, neurological, psychiatric and motor disorders like (fractures, diagnosis of Osteoporosis)

2. Patients taking any medication for mild cognition.

3. Depressive symptoms, acute and chronic conditions that would preclude exercise, regular exercise (>30 min/day, >3days/week).

4. Patients having estrogen replacement therapy.

5. Simultaneous participation in other studies.

6. Regular physical activity (once a week during the last 3 months); physio therapeutic treatment in the last 3 months.

7. Diseases that promote incapacity; severe visual deficiency; recurrent vertigo; and uncontrolled systemic arterial hypertension.

Related Conditions & MeSH terms

• Cognitive Dysfunction
• Mild Cognitive Impairment

Intervention

Other:
• RESISTED EXERCISES
Patients will perform Chest plank for 30 seconds with 4 repetitions. Then the Participants will perform these exercises for 1 minute each with 4 repetitions: Wide grip lateral pull down , Lying triceps press, Sit up squats, Barbell curl each. And will perform Thigh adduction for1 minute with 2 repititions.
• BALANCE EXERCISES
Static and dynamic balance exercises will include: Patients will perform Arm abduction holding a half-kg dumbbell, Opposite arm and leg in a quadruped position, Walking in a tandem stance(forward and backward), Turning and bending to the sides in a standing position, Pass through obstacles in a spiral, for 2 minutes each. Then they will perform throwing a medicine ball to investigator and back while trying to maintain balance, Tandem stance, Walking backwards, Two-leg bridge as well as single (2 repetitions), Leg bridge (raising the other leg), walking on the heel, performing rhythmic movements while stepping on a circular environment and balance board exercises, for 1 minute each. And will Walk up and down the stairs for 3 minutes.

Locations

Country	Name	City	State
Pakistan	Riphah International University	Lahore	Punjab

Sponsors (1)

Lead Sponsor	Collaborator
Riphah International University

Country where clinical trial is conducted

Pakistan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	MoCA (Montreal Cognitive Assessment )	The Montreal Cognitive Assessment (MoCA) will be used as a screening tool as well as assessment tool for cognition. It is a one-page, 30-point cognitive screening measurement scale that takes about 10 minutes to administer	14th week
Primary	Mini-Balance Evaluation Systems Test (BESTest).	It aims to target and identify 6 different balance control systems so that specific rehabilitation approaches can be designed for different balance deficits.It is a 14-item test scored on a 3-level ordinal scale.	16th week
Primary	Timed UP and GO Test (TUG) :	The Timed Up and Go test (TUG) will be used as a screening as well as assessment scale for balance and motor function. It can measures in seconds the time it takes a subject to rise from a chair, walk a distance of 3 meters, turn, walk back to the chair and sit down.This test has been used extensively in geriatric medicine to examine balance, gait speed, and functional ability that would be required for the performance of basic activities of daily living in older people.	16th week
Primary	Computerized battery test (CBT)	The battery is designed for preclinical screening of abnormal cognitive decline. It comprises 8 sub tests that assess 4 cognitive domains: attention, executive function, processing speed, and memory (verbal, nonverbal, functional, and incidental).	16th week