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Clinical Trial Summary

2X-121 is a small molecule targeted inhibitor of Poly ADP ribose polymerase (PARP), a key enzyme involved in DNA damage repair in cancer cells. The PARP inhibitor demonstrated clinical activity in a prior Phase 1 study in a number of solid tumors. 2X-121 has a novel dual-inhibitory action against both PARP 1/2 and Tankyrase 1/2. The molecule is also active in P-glycoprotein expressing cells, suggesting it may overcome some of the PARP inhibitor resistance. The Phase 2 study is using 2x-121 DRP® biomarker in metastatic breast cancer patients to identify patients likely to respond to and benefit from treatment with 2X-121.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03562832
Study type Interventional
Source Allarity Therapeutics
Contact
Status Active, not recruiting
Phase Phase 2
Start date June 20, 2018
Completion date May 2024

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