Obesity Clinical Trial
Official title:
Vascular Function Markers: Differences Between Lean and Abdominally Overweight / Obese Men and Effects of Weight Loss
An increased body mass impairs vascular function (VF), an important characteristic of
subjects suffering from type 2 diabetes and a risk marker for cardiovascular diseases.
However, a wide variety of in vivo VF markers exists each measuring different aspects of VF.
Each of these markers addresses a different aspect of the vasculature. Studies comparing
under standardized conditions the differences and relationships of the many different VF
measurements in lean and abdominally overweight / obese subjects are missing. Also, there is
a great need to know which of these markers are sensitive to dietary challenges.
Therefore, it is imperative to conduct an extensive study on dietary effects and
interrelationships of a broad spectrum of VF measurements and plasma biomarkers in lean and
overweight / obese subjects. Focus will be on FMD, a well accepted biomarker for
cardiovascular disease. The investigators propose to examine, in a two-way
parallel-randomized human intervention study, the effects of weight-loss in abdominally
overweight / obese men on VF markers and plasma biomarkers related to low-grade inflammation
and vascular activity during the fasting and both the postprandial and hyperinsulinemic
state. Furthermore, differences - and relations between - VF measurements and plasma
biomarkers will be compared cross-sectionally between lean and abdominally overweight /
obese male subjects.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Basic Science
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