Aerobic Exercise and High-Intensity Interval Training

Mental Health Clinical Trial

Official title: Effects of Aerobic Exercise and High-Intensity Interval Training on the Mental Health of Adolescents Living in Poverty

Status Not yet recruiting

Clinical Trial Summary

The increasing rate of mental health issues among adolescents has recently been a considerable concern in Hong Kong. In particular, adolescents with low socioeconomic status (SES) are likely to experience poor mental health including low self-esteem and high levels of anxiety, anger, and depression. Previous research has found that physical activities have a positive impact on improving mental health outcomes among adolescents. However, approximately 96% of adolescents in Hong Kong fail to engage in regular exercises, which potentially increase risk of poor mental health. This study aims to (1) examine whether changes in the three indicators (reduced ill-being, enhanced well-being and cognitive functions) of mental health among adolescents with low socioeconomic status are evident before and after exercises. In addition, this study (2) compares the effectiveness of aerobic exercise and high-intensity interval training in these indicators among adolescents with low SES. A range of neuropsychological tests and psychometric scales will be used to measure the executive functions and indicators of psychological well-being and ill-being, which include enjoyment, self-efficacy, mood, depression, anxiety, and stress. It is hoped that the findings will help inform policymakers and practitioners for promoting the importance of physical exercises to enhance mental health.

Clinical Trial Description

Adolescents' poor mental health provides serious implications for adult morbidity and mortality. Mental health involves the absence of mental illness and life satisfaction. In Hong Kong (HK), the mental health of adolescents has been a subject of considerable concern in recent years. A recent survey of 11,493 local citizens revealed that approximately 74% of adolescents below the age of 25 years exhibit moderate to high levels of depressive symptoms (e.g., depression, anxiety, and stress), 41% suffer moderate to high levels of post-traumatic stress symptoms, and 36% have both diagnoses. Previous research has also demonstrated that poor mental health is unevenly distributed across different socioeconomic groups and is highly clustered in families with socioeconomic status (SES).

Families with low SES are more deprived in multiple ways and suffer from numerous stressors related to finances, social relations, employment opportunities, and physical illness than families from other socioeconomic groups. For instance, adolescents with low SES often have worse access to education and social participation than their peers with an average or high SES. In addition, the results from a meta-analysis study of 34 countries from 2002 to 2010 indicated that adolescents with low SES are affected by physical symptoms and have poor mental health, including low self-esteem and high levels of anxiety, anger, and depression.

Physical exercise is presently considered as an effective intervention for its safe, nonpharmacological, and cost-effective nature that can provide a range of health benefits, including improvements in body composition and physical capacity, among individuals. Recent evidence has confirmed that physical exercise provides a positive effect on mental health outcomes for youth through physiological and psychological pathways.

Studies that are focused on physiological evidence have commonly demonstrated a direct positive effect of physical exercise on the individuals' neurological processes, thereby indicating that cardio activities are directly and immediately beneficial to mental health. Two main research streams that cite physiological evidence, namely, those that focus on monoamines and those that focus on endorphins are present. The first research stream reveals that physical activity upregulates the synaptic transmission of monoamines, including the three major neurotransmitters, namely, norepinephrine, dopamine, and serotonin. A similar effect has been found for antidepressant drugs, while exercise has been proven as effective as antidepressants for alleviating depressive symptoms among patients with major depression. The hypothesis regarding endorphin is also popular for explaining the impacts of aerobic exercise on mental health. Several researchers have believed that endorphins may lead to energy conservation during exercise and consequently exhibits psychological effects such as improved mood states and reduced anxiety. Direct evidence stating that physical activity can elevate the plasma endorphin levels also exists.

Although physiological evidence has established a direct association between physical activity and mental health, researchers are also keen to identify how physical activities may benefit mental health. Several researchers have conducted studies based on the three indicators of mental health that were proposed by Costigan et al. (2016), namely, (1) cognitive function, (2) well-being (e.g., enjoyment), and (3) ill-being (e.g., depression, negative affect).

With regard to cognitive function, a growing evidence indicates that participating in exercise positively affects the executive functions. Executive function is an umbrella term, which covers a wide array of cognitive processes that govern goal-directed actions and adaptive responses to novel, complex, or ambiguous situations. Numerous studies have found that intense physical exercise improves working memory inhibitory control, and cognitive flexibility in typical and low-income adolescents.

Physical exercise has been associated with improved well-being, including life satisfaction and self-esteem. Exercise is a challenging activity, but the process of engaging in exercise could provide individuals with a meaningful experience of mastery that may lead to improved mood states and self-confidence. Affect regulation theory suggests that exercise could regulate affect by reducing negative mood states and enhancing positive mood states conducive to mental well-being. Furthermore, as described in relevant literature, exercise could divert an individual from unfavourable stimuli (e.g., worries, stress, and depressive thoughts) leading to improved moods.

Physical exercise has also been associated with reduced ill-being. A meta-analysis of 73 studies confirmed that increased levels of physical activity exhibit significant effects on reducing depression, anxiety, psychological distress, and emotional disturbance among children Archer and Garcia (2017) found that regular physical exercise ameliorated the symptoms of anxiety and depression. Behavioral activation theory posits that depressive symptoms may be alleviated when individuals replaced passive activities with exercise and other entertaining activities.

Although a lack of consensus regarding the most effective training regimen for physical exercise is evident in clinical review studies from 2000 to 2014, Ranjbar et al. (2015) recommended the following components of an effective exercise program to benefit adolescents with poor mental health. Based on the frequency, intensity, time, and type (FITT) principle, an exercise program should include the characteristics, namely, (1) structured aerobic exercise, which requires the heart to pump oxygenated for delivering oxygen to working muscles and stimulates an increase in the heart rate (HR) and breathing rate; (2) group exercise, particularly for adolescents; (3) low (40%-55% VO2max) to moderate (65%-75% VO2max) intensity; (4) 45 to 60 minutes length of session; (5) frequency of at least three to four times per week, which is equal to 150 or above minutes of exercise per week; and (6) a duration equal to 10 weeks or above.

Overall, the extensive research has confirmed that physical exercise can significantly improve physical and mental health, while aerobic exercise has been the main focus of most previous studies. Research has recently been attempted to determine whether low-volume HIIT could be a time-efficient exercise strategy for improving health and fitness among the general population.

HIIT is a time-efficient type of aerobic training that involves a short duration of full-effort exercise, followed by a rest period. HIIT is mainly appealing because it can be completed in a relatively short period that results in equivalent physiological adaptations of long sessions of traditional aerobic training and improvements in physical and mental health. This strategy may be feasible and effective for increasing physical health outcomes among young people. Compared with low-intensity, high-volume (duration) endurance aerobic training (i.e., cycling), HIIT can result in better oxygen uptake, greater muscle deoxygenation, and better exercise performance. A previous study also revealed that patients participating in high-intensity interval running reported higher perceived enjoyment than those participating in moderate-intensity continuous running. A pilot study of a 10-week HIIT program resulted in improved metabolic outcomes among patients with schizophrenia, thereby supporting the benefits of HIIT for physical fitness and mental health. Further studies have also shown that HIIT reduces distress and anxiety.

Despite the promising evidence that supports the adoption of HIIT among adults with various conditions, limited research that targets adolescents, particularly those with low SES, is available. High-intensity activities performed in short, repeated bouts with periods of recovery in-between could be an achievable and enjoyable alternative to high-volume continuous exercise for adolescents, including "low-active" adolescents.

The conditions and ability of poor individuals to manage and potentially escape from poverty are the core of policy agendas and the ethical and economic concerns among societies. Behavioral research has recently been applied to policy-relevant challenges and has explored the significant potential of simple interventions to influence cognition and behavior. Poor individuals, particularly young poor individuals in HK, have received little attention as part of this endeavour despite their characteristics that satisfy the qualifications of clear candidates for interventions that could improve disadvantaged situations.

Although several longitudinal studies have confirmed that growing up in a disadvantaged family is a significant risk factor of poor mental health, numerous research gaps should be addressed by further investigation. For instance, most studies on mental health and socioeconomically disadvantaged adolescents have been restricted to understanding and confirming the link between mental health and SES. Research that aims to examine whether mental health could be enhanced through physical exercise is scarce. However, such research would be extremely meaningful for expanding early interventions. To date, a steady decline in the number of physically active students in HK is evident. Furthermore, the situation among adolescents in HK is worse given that 96% of them are insufficiently active. Hence, a considerable need for this kind of research arises to arouse public awareness on the link between physical activity and mental health. Although previous studies have reported the improvements in the mental health of adolescents after exercise sessions, a lack of follow-up data is available on assessing the sustainability of the exercise intervention with moderate intensity under long duration. In addition, relatively few studies directly compared the effects of aerobic exercise and HIIT on the mental health of adolescents with low SES. Given that HIIT training has become popular and effective on improving health and well-being, HIIT exercise should be used as the comparison group to examine the effectiveness of traditional aerobic exercise.

Following the health benefits of regular exercise and the limited research on exercise-based interventions (aerobic exercise vs. HIIT) with low-SES adolescents, this study primarily aims to investigate the effectiveness of aerobic exercise and HIIT on the three indicators of mental health among low-SES adolescents. This paper particularly intends to answer two research questions, namely, (1) Is there any change in the three indicators of mental health (i.e., cognitive function, well-being, and ill-being) before and after exercise? (2) Which exercise regimen (aerobic exercise or HIIT) is more effective in reducing ill-being and enhancing well-being and cognitive function among adolescents with low SES? ;

Related Conditions & MeSH terms

• Mental Health

• NCT number: NCT05029388
• Study type: Interventional
• Source: Education University of Hong Kong
• Contact: Kei Yan Kean POON
• Phone: 2948 8303
• Email: kean@eduhk.hk
• Status: Not yet recruiting
• Phase: N/A
• Start date: January 3, 2022
• Completion date: September 1, 2023