Combination Chemotherapy Plus Biological Therapy in Treating Patients With Metastatic Melanoma

Melanoma (Skin) Clinical Trial

Official title:

Phase II Study of Outpatient CDDP and DTIC Followed by GM-CSF, IFN-a2b, and IL-2 in Patients With Advanced Melanoma

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00004141
• Other study ID #: 9372
• Secondary ID: UCCRC-9372UCCRC-
• Status: Completed
• Phase: Phase 2
• First received: December 10, 1999
• Last updated: September 4, 2013
• Start date: August 1998
• Est. completion date: April 2006

Study information

• Verified date: September 2013
• Source: University of Chicago
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Biological therapies use different ways to stimulate the immune system and stop cancer cell from growing. Combining more than one drug with different types of biological therapies may kill more tumor cells.

PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy plus biological therapy in treating patients who have metastatic melanoma.

Description:

OBJECTIVES:

• Determine the toxicity of cisplatin and dacarbazine followed by sargramostim (GM-CSF), interferon alfa, and interleukin-2 in patients with metastatic melanoma.

• Determine the objective response rate, relapse free survival, and overall survival of these patients on this regimen.

OUTLINE: Patients receive cisplatin IV over 1 hour and dacarbazine IV over 30-60 minutes sequentially on day 1, followed by sargramostim (GM-CSF) subcutaneously (SC) on days 2-7, interleukin-2 SC on days 8-14, and interferon alfa SC on days 8, 10, 12, and 14. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.

Patients are followed every 8 weeks until disease progression, and then every 8-12 weeks thereafter.

PROJECTED ACCRUAL: A total of 15-45 patients will be accrued for this study within 3 years.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 46
• Est. completion date: April 2006
• Est. primary completion date: January 2003
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A and older

Eligibility

DISEASE CHARACTERISTICS:

• Histologically confirmed metastatic melanoma

• Stage III with intransit metastases

• Stage IV

• No uncontrolled brain metastases by CT scan

• No clinically significant ascites or pleural effusions

PATIENT CHARACTERISTICS:

Age:

• Not specified

Performance status:

• Karnofsky 70-100%

Life expectancy:

• At least 10 weeks

Hematopoietic:

• WBC at least 3,000/mm^3

• Platelet count at least 100,000/mm^3

• Hemoglobin at least 9.5 g/dL

Hepatic:

• Bilirubin no greater than 2.0 mg/dL

• SGOT no greater than 4 times upper limit of normal

Renal:

• Creatinine no greater than 1.5 mg/dL OR

• Creatinine clearance at least 70 mL/min

Cardiovascular:

• No clinically significant cardiac disease on EKG, echocardiogram, or MUGA scan

Pulmonary:

• No clinically significant pulmonary disease on chest x-ray

Other:

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• No significant thyroid dysfunction

• No concurrent severe infection

• No other medical or psychiatric condition that would interfere with compliance

• No second malignancy within the past 5 years, except:

• Localized nonmelanomatous skin cancer

• Carcinoma in situ of the cervix

• Grade 1 Ta bladder cancer

• Suspected hearing deficits must undergo audiologic testing

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• No more than one prior immunotherapy regimen

• At least 4 weeks since prior immunotherapy

• Adjuvant interferon alfa before relapse allowed

Chemotherapy:

• No more than one prior chemotherapy regimen

• At least 4 weeks since prior chemotherapy (6 weeks since nitrosoureas)

• No concurrent cyclophosphamide

• No other concurrent chemotherapy

Endocrine therapy:

• No concurrent corticosteroids or cyclosporine A

Radiotherapy:

• At least 2 weeks since prior radiotherapy

Surgery:

• At least 3 weeks since major surgery

Other:

• No concurrent immunosuppressive drugs

• No other concurrent investigational antineoplastic drugs

• Concurrent thyroid replacement therapy allowed

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Melanoma
• Melanoma (Skin)

Intervention

Drug:
• Cisplatin

• dacarbazine

• Granulocyte-macrophage colony-stimulating factor

Locations

Country	Name	City	State
United States	University of Chicago Cancer Research Center	Chicago	Illinois

Sponsors (2)

Lead Sponsor	Collaborator
University of Chicago	National Cancer Institute (NCI)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Objective response rate		2 years	No