Vaccine Therapy in Treating Patients With Melanoma

Melanoma (Skin) Clinical Trial

Official title:

Phase Ib Trial of Intratumoral Injection of a Recombinant Canarypox Virus Encoding Human B7.1 (ALVAC-hB7.1) or a Combination of ALVAC-hB7.1 and a Recombinant Canarypox Virus Encoding Human Interleukin 12 (ALVAC-hIL-12) in Patients With Surgically Incurable Melanoma

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00003556
• Other study ID #: NCI-2012-02274
• Secondary ID: UAB-9705NCI-T97-
• Status: Completed
• Phase: Phase 1
• First received: November 1, 1999
• Last updated: February 7, 2013
• Start date: January 1999

Study information

• Verified date: February 2013
• Source: National Cancer Institute (NCI)
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

Phase I trial to study the effectiveness of vaccine therapy in treating patients with melanoma that cannot be treated with surgery. Vaccines may make the body build an immune response that may kill tumor cells. Combining more than one vaccine may kill more tumor cells.

Description:

OBJECTIVES:

I. Determine the toxic effects associated with ALVAC-hB7.1 alone or combined with ALVAC-hIL-12 in patients with surgically incurable melanoma.

II. Characterize the inflammatory and lymphokine response to this regimen in these patients.

III. Examine the extent of nodule regression, humoral immune response, and cytolytic T cell activity with this regimen in these patients.

OUTLINE: This is a dose escalation study of ALVAC-hB7.1

Patients receive ALVAC-hB7.1 alone or combined with ALVAC-hIL-12 intratumorally on days 1, 4, 8, and 11. Treatment continues in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients are treated at each dose level of ALVAC-hB7.1. The maximum tolerated dose is defined as the dose of ALVAC-hB7.1 at which no more than 1 of 5 patients experiences dose limiting toxicity.

Patients are followed at 1, 2, 4, 8, 11, 15, 22, and 43 days after the first vaccination.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 15
• Est. primary completion date: May 2001
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

DISEASE CHARACTERISTICS:

• Histologically confirmed melanoma that is surgically incurable

• At least one dermal, subcutaneous or lymph node metastasis that is evaluable for local response and accessible for injection

• If only one accessible lesion is available, it must be at least 2 cm

• If two or more accessible lesions exist, then none of them are required to be at least 2 cm

PATIENT CHARACTERISTICS:

• Age: Over 18

• Performance status: ECOG 0-2

• Life expectancy: Greater than 3 months

• Leukocyte count at least 3,000/mm3

• Platelet count at least 120,000/mm3

• SGOT and alkaline phosphatase less than 5 times normal

• Bilirubin less than 1.5 mg/dL (unless secondary to hepatic metastasis)

• BUN less than 40 mg/dL

• Creatinine less than 2.5 mg/dL

• No evidence of congestive heart failure, unstable angina, or serious cardiac arrhythmias

• Not positive for hepatitis B virus

• Not positive for HIV

• No history of allergy to vaccinia virus

• No evidence of other primary tumors except for basal cell carcinoma, squamous cell skin carcinoma, or carcinoma in situ of the cervix

• Not pregnant or nursing

• Fertile patients must use effective contraception

• No underlying immunodeficiency disorder

PRIOR CONCURRENT THERAPY:

• At least 30 days since prior biologic therapy (e.g., interferon or IL-2)

• At least 30 days since prior chemotherapy

• No concurrent steroids

• At least 30 days since prior radiotherapy

• Prior radiotherapy to no greater than 50% of nodal groups

• No prior splenectomy

• No concurrent drugs which affect immune function (e.g., glucocorticoids or cimetidine)

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Melanoma
• Melanoma (Skin)

Intervention

Biological:
• ALVAC-hB7.1

• canarypox-hIL-12 melanoma vaccine

Locations

Country	Name	City	State
United States	University of Alabama Comprehensive Cancer Center	Birmingham	Alabama

Sponsors (1)

Lead Sponsor	Collaborator
National Cancer Institute (NCI)

Country where clinical trial is conducted

United States,