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Safety and Protective Efficacy of Pb(PfCS@UIS4) — PbVac  

Malaria,Falciparum Clinical Trial

Official title:
Safety and Protective Efficacy of Genetically Modified Plasmodium Berghei (Pb(PfCS@UIS4)) Malaria Parasites in Healthy Volunteers

Clinical Trial Summary

In the underlying study, a genetically modified P. berghei parasite is used. P. berghei is one of the four Plasmodium species that causes malaria in rodents. The hypothesis is that immunization of humans with P. berghei will induce a cross-species immune response without the risk of a breakthrough infection. To further increase the potential for protective efficacy, the P. falciparum circumsporozoite (CS)- protein gene has been integrated in the P. berghei parasite, generating a genetically modified P. berghei parasite, abbreviated as Pb(PfCS@UIS4).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03138096
Study type Interventional
Source Radboud University Medical Center
Contact
Status Completed
Phase Phase 1/Phase 2
Start date May 29, 2017
Completion date October 3, 2018
View Details
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