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Clinical Trial Summary

The effectiveness of glabellar injection of botulinum toxin type A (BTA) in treating depression has not yet been investigated in elderly patients. The study aims in addressing the question if glabellar injection of BTA is effective in treating geriatric depression.


Clinical Trial Description

Feedback from facial expressions is known to influence emotional experience. Treatment of muscles involved in facial expression of sadness, anger or anxiety with botulinumtoxin showed a quick, strong and sustained improvement in the symptoms of depression. As considerable proportion of patients do not sufficiently respond to existing treatment options. Especially in the elderly current treatments show limited response or are associated with side effects. Injections with BTA are considered as a very safe treatment without lasting side effects. The aim of the study is to investigate effectiveness of BTA in treating major depression in the elderly in a cross-over designed, placebo-controlled manner. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03833063
Study type Interventional
Source Helse Stavanger HF
Contact Benedikt CG Römer, Dr. med.
Phone 004740540210
Email benedikt.romer@sus.no
Status Not yet recruiting
Phase Phase 1
Start date March 1, 2019
Completion date March 31, 2020

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