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Ketamine and Scopolamine Infusions for Treatment-resistant Major Depressive Disorder

Major Depressive Disorder Clinical Trial

Official title:
Combination of Anticholinergic and Glutamatergic Effects in Treatment-resistant Major Depressive Disorder. A Pilot Study

Clinical Trial Summary

Ketamine infusions resulted in an acute reduction in global depression scores and in severity of suicidal ideation. Scopolamine infusions produced also a significant improvement in depression that was sustained over time.

We therefore plan to investigate the feasibility and efficacy of open-label repeated intravenous administration of ketamine and scopolamine combined in this population of severely depressed, treatment-resistant patients. The results from this study could lead to the development of new strategies for the treatment of patients with TRD.

Clinical Trial Description

Patients will undergo two weeks of prospective observation, they will then receive IV infusions of ketamine, scopolamine or both per randomization as augmentation of their ongoing antidepressant regime. The schedule of administration will be twice a week of three weeks. After this phase the subject will be followed with assessments every two weeks for three months. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01613820
Study type Interventional
Source Massachusetts General Hospital
Contact
Status Withdrawn
Phase N/A
Start date September 2015
Completion date February 2017
View Details
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