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Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Patients Meeting Chinese Lynch Syndrome Criteria

Lynch Syndrome Clinical Trial

Official title:
Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Colorectal Cancer Patients Meeting Chinese Lynch Syndrome Criteria: An Open-label and Multi-center Study.

Clinical Trial Summary

The purpose of this study is to find out the proportion of patients diagnosed with Lynch syndrome in colorectal cacner patients meeting Chinese Lynch syndrome criteria. Besides, this study is aimed to analyze the clinical characteristics and germline mutation of Lynch syndrome in Chinese population.

Clinical Trial Description

1. Detect germline mutation (by next-generation squencing) in probands. 2. Verify the germline mutation in blood relatives whose proband has known germline mutation(s). 3. Analyze the test data with clinical and family information. Diagnose Lynch syndrome in the included population. 4. Analyze the clinical characteristics and germline mutation of Lynch syndrome in Chinese population. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03046849
Study type Observational
Source Second Affiliated Hospital, School of Medicine, Zhejiang University
Contact
Status Completed
Phase
Start date March 8, 2017
Completion date February 26, 2019
View Details
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