Lynch Syndrome Clinical Trial
Official title:
Specialized Program of Research Excellence (SPORE) in Endometrial Cancer
This research study is studying biomarkers in samples from patients with endometrial cancer. Studying samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PRIMARY OBJECTIVES:
I. Assess the frequency and spectrum of mutations in fibroblast growth factor receptor 2
(FGFR2) in low-, intermediate-, and/or high-risk endometrioid endometrial cancer from
GOG-0210. (Project 1) II. Determine the relationship between FGFR2 mutation and
clinicopathologic variables including disease-free and overall survival in low-,
intermediate-, and/or high-risk endometrial cancer from GOG-0210. (Project 1) III. Identify
the cognate FGF ligands and receptors expressed in normal endometrium and endometrial
cancers, and examine their expression on multiple tissue microarrays for GOG-0210 to
determine their association with clinical outcome. (Project 1) IV. Identify epigenetic
biomarkers (differential methylation of CpG island loci) associated with recurrence and
disease progression in endometrioid endometrial cancer from Washington University School of
Medicine (WUSM). (Project 2) V. Confirm epigenetic biomarkers (differential methylation of
CpG island loci) associated with recurrent and disease progression in endometrioid
endometrial cancer from GOG-0210. (Project 2) VI. Define the performance (sensitivity and
specificity) of epigenetic biomarkers associated with recurrence and disease progression in
endometrioid endometrial cancer from an independent cohort of cases from GOG-0210. (Project
2) VII. Develop a molecular screening regimen to compliment family history risk assessment
to identify carriers of Hereditary Non-Polyposis Colorectal Cancer (HNPCC)-related and other
forms of inherited endometrial cancer from GOG-0210 that was not ascertained by family
history. (Project 3) VIII. Estimate the prevalence of HNPCC-related and other forms of
inherited endometrial cancer in GOG-0210. (Project 3) IX. Define the relationship between
defective DNA mismatch repair and clinical and epidemiological factors in GOG-0210. (Project
3) X. Determine the clinicopathologic significance of mismatch-repair defects including
associations with disease-free and overall survival in GOG-0210. (Project 3) XI. Assess
expression of five candidate ERK1/2 substrates in the normal endometrium, primary
endometrial cancers (from WUSM and GOG-0210) and endometrial cancer cell lines and determine
if substrate phosphorylation is ERK-dependent. (Project 4) XII. Determine the relationship
between ERK substrate-phosphorylation status and upstream ERK-signaling pathway activation
in primary endometrial cancers from WUSM and GOG-0210. (Project 4 XIII. Determine the
clinicopathologic significance of ERK substrate expression in primary endometrial cancers
from WUSM and GOG-0210. (Project 4) XIV. Explore GSK3/3 inhibition as a therapeutic
treatment of endometrial cancer and assess the role of inhibiting other ERK substrates in
endometrial cell lines. (Project 4) XV. Explore the predictive and prognostic accuracy of a
panel of single nucleotide polymorphisms alone and with informative clinical, surgical, and
pathologic variables in a cohort of Caucasian women with stage IB or IC vs IIIC endometrioid
endometrial cancer from WUSM and GOG-0210. (Project 5)
OUTLINE: This is a multicenter study.
Previously collected samples are analyzed for biomarker and other laboratory analyses.
;
Time Perspective: Retrospective
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