Lymphoma Clinical Trial
Official title:
Autologous Blood Stem Cell Transplantation in Patients With Hodgkin's Disease and Non-Hodgkin's Lymphoma With High-Dose Cyclophosphamide, Total Body Irradiation and Involved-Field Radiation Therapy
RATIONALE: Radiation therapy uses high-energy x-rays to damage cancer cells. Drugs used in
chemotherapy use different ways to stop cancer cells from dividing so they stop growing or
die. Peripheral stem cell transplantation may allow doctors to give higher doses of
chemotherapy drugs and kill more cancer cells.
PURPOSE: Phase II trial to study the effectiveness of radiation therapy and cyclophosphamide
plus peripheral stem cell transplantation in treating patients who have recurrent or
refractory Hodgkin's disease or non-Hodgkin's lymphoma.
OBJECTIVES: I. Determine the toxicity of autologous peripheral blood stem cell
transplantation following involved field radiotherapy, high dose cyclophosphamide, and total
body irradiation in patients with recurrent or refractory Hodgkin's disease or non-Hodgkin's
lymphoma. II. Determine the response in patients treated with this regimen.
OUTLINE: Patients undergo involved field radiotherapy on days -16 to -7. Patients receive
cyclophosphamide IV over 2 hours on days -6 and -5. Patients undergo total body irradiation
twice daily on days -4 to -1. Autologous peripheral blood stem cells are reinfused on day 0.
Patients are followed every month for 1 year.
PROJECTED ACCRUAL: Not specified
;
Primary Purpose: Treatment
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