Lymphoma Clinical Trial
Official title:
Autologous Blood Stem Cell Transplantation in Patients With Hodgkin's Disease and Non-Hodgkin's Lymphoma Who Have Had Prior Radiation Therapy
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing
so they stop growing or die. Peripheral stem cell transplantation may allow the doctor to
give higher doses of chemotherapy drugs and kill more cancer cells.
PURPOSE: Phase II trial to study the effectiveness of chemotherapy followed by peripheral
stem cell transplantation in treating patients who have Hodgkin's disease or non-Hodgkin's
lymphoma.
OBJECTIVES: I. Determine the toxicity and response to intensive chemotherapy followed by
autologous peripheral blood stem cell transplantation in patients with Hodgkin's disease or
non-Hodgkin's lymphoma who have received prior chemotherapy and/or radiotherapy.
OUTLINE: Patients receive oral busulfan every 6 hours on days -9 to -6 and cyclophosphamide
IV over 2 hours on days -5 to -2. Autologous peripheral blood stem cells are reinfused on
day 0. Patients are followed monthly for 1 year.
PROJECTED ACCRUAL: Not specified
;
Primary Purpose: Treatment
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