Lymphoma Clinical Trial
Official title:
PROTOCOL FOR THE MANAGEMENT OF MYCOSIS FUNGOIDES AND THE SEZARY SYNDROME
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of etoposide with or without doxorubicin
and methotrexate in treating patients who have mycosis fungoides.
OBJECTIVES: I. Assess the response rate in patients with Stage III/IV or recurrent mycosis
fungoides or Sezary syndrome treated with oral etoposide, with the addition of doxorubicin,
then methotrexate for poor responders. II. Assess changes in the hematologic and immunologic
status of the tumor in these patients.
OUTLINE: Patients are treated sequentially on Regimens A, B, and C depending on response.
The following acronyms are used: CF Leucovorin calcium, NSC-3590 DOX Doxorubicin, NSC-123127
MTX Methotrexate, NSC-740 VP-16 Etoposide, NSC-141540 Regimen A: Single-Agent Chemotherapy.
VP-16. Regimen B: 2-Drug Combination Chemotherapy. VP-16/DOX. Regimen C: 3-Drug Combination
Chemotherapy. VP-16/DOX/MTX.
PROJECTED ACCRUAL: Study duration will be at least 3 years with an anticipated accrual of 3
patients/year.
;
Primary Purpose: Treatment
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