Occupational Exposure to Pesticides in the Prognosis of Lymphomas

Lymphoma Diffuse Large B-cell Clinical Trial

— ProLyPhy  

Official title:

Study of the Role of Occupational Exposure to Pesticides in the Prognosis of Lymphomas Diffuse Large B Cell in

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT02898870
• Other study ID #: 9668
• Status: Terminated
• Phase: N/A
• First received: September 8, 2016
• Last updated: October 9, 2017
• Start date: July 2015
• Est. completion date: April 2018

Study information

• Verified date: September 2016
• Source: University Hospital, Montpellier
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The link between the products of synthetic chemistry and cancer is at the heart of much research. Recent work has identified the use of plant protection agents by farmers as a risk factor for developing non-Hodgkin lymphoma, including diffuse large B cell lymphoma (DLBCL) is the most common histology. Different biological models were used to understand the role of pesticides in lymphomagenesis. To summarize, most pesticides act at the cellular and molecular level, on different signaling pathways. After metabolized by cytochrome P450, these compounds generally become pro-oxidants. The increase in reactive oxygen species rate (SAR) causes the activation of signaling pathways involved in cell proliferation and survival. But deregulation of oxidative status does not in itself justify the specificity of the impact of pesticides on specific pathologies. Several agents have a genotoxic effect, others induce the activation of signaling pathways by binding to transcription factors and others have immunomodulating properties.

Description:

The link between the products of synthetic chemistry and cancer is at the heart of much research. Recent work has identified the use of plant protection agents by farmers as a risk factor for developing non-Hodgkin lymphoma, including diffuse large B cell lymphoma (DLBCL) is the most common histology. Different biological models were used to understand the role of pesticides in lymphomagenesis. To summarize, most pesticides act at the cellular and molecular level, on different signaling pathways. After metabolized by cytochrome P450, these compounds generally become pro-oxidants. The increase in reactive oxygen species rate (SAR) causes the activation of signaling pathways involved in cell proliferation and survival. But deregulation of oxidative status does not in itself justify the specificity of the impact of pesticides on specific pathologies. Several agents have a genotoxic effect, others induce the activation of signaling pathways by binding to transcription factors and others have immunomodulating properties.

Among these four mechanisms by which pesticides are involved in lymphomagenesis, two are also associated with resistance to chemotherapy. Thus, genotoxic agents leads the implementation process of DNA repair, used to repair genotoxic lesions induced by chemotherapeutic agents and evade apoptosis. On the other hand, to survive a high level of ROS, the tumor cell raises the level of antioxidant defenses, maintaining redox homeostasis and preventing oxidative stress. However, a high production of antioxidants constitutes a barrier to the effectiveness of anti-tumor agents which are effective in the generation of oxidative stress.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 244
• Est. completion date: April 2018
• Est. primary completion date: October 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 100 Years

Eligibility

Inclusion Criteria:

Adults treated for diffuse large B-cell lymphoma:

• Diagnosed between 2010 and 2015

• Having received immuno-chemotherapy R-CHOP

• Supported in the health facilities of the Languedoc-Rousillon

Exclusion Criteria:

Related Conditions & MeSH terms

• Lymphoma
• Lymphoma Diffuse Large B-cell
• Lymphoma, Non-Hodgkin

Locations

Country	Name	City	State
France	LAMURE	Montpellier

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Montpellier

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	pesticide exposure	The exposure measurement will be carried out using a self-administered questionnaire sent to patients on their professional activities. If farming a second questionnaire will further characterize the exposure to pesticides	1 day