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Treatment of Lupus Nephritis With Allogeneic Mesenchymal Stem Cells — MSV_LE  

Lupus Nephritis Clinical Trial

Official title:
Phase II, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate Safety and Efficacy of Mesenchymal Stem Cells (MSV-allo) in the Treatment of Lupus Nephritis

Clinical Trial Summary

The purpose of this study is to evaluate the safety and efficacy of mesenchymal stem cells (MSCs) obtained from bone marrow for the treatment of adults with active proliferative lupus nephritis. The objective of this study is to evaluate the efficacy of mesenchymal stem cells (MSCs) in achieving a full or partial response in the treatment of Lupus Nephritis (LN) during its induction period.

Clinical Trial Description

A Phase 2b, double-blind (neither the participant nor the investigator will know if active drug or placebo is assigned), placebo-controlled, randomized (assigned by chance), in which subjects with Lupus Nephritis (LN), who do not respond -or respond partially- to induction treatment, shall receive either MSCs (2 million cells/Kg) or placebo by intravenous injection. The administration of cells will be done only once. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03673748
Study type Interventional
Source Red de Terapia Celular
Contact Julia Barbado, MD, PhD
Phone +34 983 420400
Email jbarbadoa@saludcastillayleon.es
Status Recruiting
Phase Phase 2
Start date December 27, 2022
Completion date July 2026
View Details
See also
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