Lung Cancer Clinical Trial
Official title:
Positron Emission Tomography Using 11C Topotecan in Predicting Response to Treatment in Patients With Brain Metastases Due to Ovarian, Small Cell Lung, or Other Cancer
RATIONALE: Diagnostic procedures, such as positron emission tomography (PET scan) using 11C
topotecan, may help doctors predict a patient's response to treatment and help plan the best
treatment.
PURPOSE: This phase I/II trial is studying how well a PET scan using 11C topotecan predicts
response to treatment in patients with brain metastases due to ovarian, small cell lung, or
other cancer.
OBJECTIVES:
Primary
- Determine if tumor uptake of ^11C topotecan occurs quickly enough and at sufficient
concentration to be measured immediately following infusion in patients with brain
metastases secondary to ovarian cancer, small cell lung cancer, or other cancers.
- Determine, preliminarily, if ^11C imaging has potential to be an early predictor of
response to topotecan therapy in these patients.
Secondary
- Determine the whole-body biodistribution of ^11C topotecan in these patients.
OUTLINE:
- Phase I: Patients receive ^11C topotecan IV over 10 minutes followed immediately by a
1-2 hour positron emission tomography (PET) scan. Within 4 weeks after initial imaging,
patients also undergo a CT scan.
- Phase II: Patients receive ^11C topotecan and undergo imaging as in phase I. Patients
also receive fludeoxyglucose F 18 IV and, 1 hour later, undergo a PET scan.
PROJECTED ACCRUAL: A total of 10 patients will be accrued for this study.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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