Leukemia Clinical Trial
Official title:
CAMPATH-1H Compassionate Treatment In Patients With PLL Who Have Failed At Least One Prior Regimen And CLL Patients Who Have Failed Fludarabine Therapy
RATIONALE: Monoclonal antibodies can locate cancer cells and either kill them or deliver
cancer-killing substances to them without harming normal cells. Compassionate use refers to
providing a drug to a patient on humanitarian grounds before the drug has received official
approval.
PURPOSE: Compassionate use of Campath-1H in treating patients who have refractory
prolymphocytic leukemia or chronic lymphocytic leukemia.
OBJECTIVES: I. Expand access to Campath-1H for patients with refractory prolymphocytic
leukemia or chronic lymphocytic leukemia.
OUTLINE: Patients receive Campath-1H IV over 2 hours on days 1, 3, and 5. Treatment repeats
weekly for 4-12 weeks in the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: Not specified
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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