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A Phase 2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Myelofibrosis

Leukemia Clinical Trial

Official title:
A Phase 1/2 Study of CPI-0610, a Small Molecule Inhibitor of BET Proteins: Phase 1 (Dose Escalation of CPI-0610 in Patients With Hematological Malignancies) and Phase 2 (Dose Expansion of CPI-0610 With and Without Ruxolitinib in Patients With Myelofibrosis and Essential Thrombocytopenia)

Clinical Trial Summary

Phase 1 Part (Complete): Open-label, sequential dose escalation study of pelabresib in patients with previously treated Acute Leukemia, Myelodysplastic Syndrome, Myelodysplastic/Myeloproliferative Neoplasms, and Myelofibrosis. Phase 2 Part: Open-label study of CPI-0610 with and without Ruxolitinib in patients with Myelofibrosis. CPI-0610 is a small molecule inhibitor of bromodomain and extra-terminal (BET) proteins.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Bone Marrow Disease
  • Bone Marrow Diseases
  • Essential Thrombocytosis
  • Hematologic Diseases
  • Hematological Disease
  • Leukemia
  • Leukemia, Myelocytic, Acute
  • Leukemia, Myeloid
  • Leukemia, Myeloid, Acute
  • Myelodysplastic Syndrome (MDS)
  • Myelodysplastic Syndromes
  • Myelodysplastic-Myeloproliferative Diseases
  • Myelodysplastic/Myeloproliferative Neoplasm
  • Myelofibrosis
  • Myeloproliferative Disorders
  • Neoplasms
  • Neoplasms by Histologic Type
  • Precancerous Conditions
  • Preleukemia
  • Primary Myelofibrosis
  • Thrombocythemia, Essential
  • Thrombocytosis
Clinical Trial Details
NCT number NCT02158858
Study type Interventional
Source Constellation Pharmaceuticals
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date July 16, 2014
Completion date October 31, 2024
View Details
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