Clinical Trials Logo

Clinical Trial Summary

This pilot study is designed as a multi-centre cohort study determining the degree of LV reverse remodeling in patients with intermediate QRS widths (120-149ms) who undergo CRT implant with transseptal LV leads, and comparing to the average expected reverse remodeling rate in patients with standard transvenous coronary sinus leads and QRS widths ≥150ms.


Clinical Trial Description

This is a multi-centre prospective cohort trial to establish the feasibility of endocardial CRT implants.This trial will assess feasibility of a larger scale randomized controlled study.

Patients consented to the study will receive a CRT device with or without ICD, placed in the same time frame, and will have RA and RV leads implanted as the standard of care. The device will be implanted in a facility that has the capacity to perform trans-atrial septal puncture with ultrasound guidance (TEE or ICE) at the time of implantation. The LV lead will be placed using a trans-atrial septal approach, using specially designed puncture tools and LVendo delivery tool kits specifically designed for this study. Special care will be taken to avoid the LV apex and transmural scar identified by pre-implant imaging. Electrical testing, and programming of the device will be standardized. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03573427
Study type Observational
Source Lawson Health Research Institute
Contact
Status Withdrawn
Phase
Start date April 28, 2016
Completion date July 22, 2019

See also
  Status Clinical Trial Phase
Enrolling by invitation NCT05529654 - IMpella-Protected cArdiaC Surgery Trial (IMPACT) N/A
Recruiting NCT04671966 - Sex Differences in Myocardial Steatosis Induced Left Ventricular Dysfunction Phase 4
Not yet recruiting NCT05188222 - Preoperative Maltodextrin's Effect on Cardiac Function in Cardiac Surgery Phase 4
Recruiting NCT04950218 - The Psoriasis Echo Study
Completed NCT01076920 - Mesenchymal Stem Cells and Myocardial Ischemia Phase 1/Phase 2
Completed NCT01128790 - Pilot Study of Remote Ischemic Preconditioning in Heart Failure N/A
Completed NCT04942353 - Effects of Home-based Exercise Rehabilitation on Healthcare Utilization in HeartMate 3 Patients N/A
Recruiting NCT05769036 - Conventional Biventricular Versus Left Bundle Branch Pacing on Outcomes in Heart Failure Patients N/A
Completed NCT03232736 - InterventiOn of Biventricular Pacemaker Function on ventrIcular Function Among Patients With LVAD's
Recruiting NCT04694092 - Landiolol for Rate Control in Decompensated Heart Failure Due to Atrial Fibrillation N/A
Completed NCT01609738 - Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular Septum Phase 1/Phase 2
Completed NCT02013037 - The De-novo Use of Eculizumab in Presensitized Patients Receiving Cardiac Transplantation Phase 3
Completed NCT00551681 - Effects of Left Ventricular Pacing Optimilization on Cardiac Perfusion, Contractile Force, and Clinical Performance in Patients With Ventricular Dysfunction and Heart Failure N/A
Not yet recruiting NCT04103008 - Left Ventricular Function After Primary Percutaneous Coronary Intervention: Role of Speckle Echocardiography
Completed NCT06197256 - Cardiac Dysfunction in Critically Ill Covid-19 Patients
Recruiting NCT05860504 - Acute Cardiac Dysfunction in Critical Illnes
Completed NCT03787810 - Left Ventricular Dysfunction in Critically Ill Patients
Completed NCT01093001 - Tricuspid Regurgitation Study Phase 4
Active, not recruiting NCT00461734 - PROTECT-PACE STUDY - The Protection of Left Ventricular Function During Right Ventricular Pacing N/A
Recruiting NCT04752293 - Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)