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NCT number NCT03498235
Study type Interventional
Source Obstetrics & Gynecology Hospital of Fudan University
Contact
Status Enrolling by invitation
Phase Early Phase 1
Start date March 1, 2018
Completion date August 2018

Clinical Trial Summary

Intracranial pressure(ICP) increases during laparoscopic gynecologic surgery increase (ICP) and may alter optic nerve sheath diameter(ONSD).This study measures ONSD in different team because sevoflurane and propofol have different effects on ICP.Half of participants will receive sevoflurane anesthesia,while the other half undergo propofol anesthesia.


Clinical Trial Description

Due to the anatomical and physiological characteristics of optic nerve sheath ,ONSD increases when ICP rises.

Sevoflurane and propofol have different effects on ICP.When sevoflurane concentration >1.1 minimum alveolar concentration(MAC),ICP increases because of cerebral vasodilatation;on the other hand ,propofol constricts the blood vessels and ICP decreases.

ICP increases during laparoscopic gynecologic surgery because of steep Trendelenburg position and pneumoperitoneum .

Meanwhile,sevoflurane affects self regulation of cerebral blood flow on the way of dose dependent,but propofol has no effects on self regulation of cerebral blood flow.


Study Design


Related Conditions & MeSH terms