The Effect of Adipose-Derived Stem Cells for Knee Osteoarthritis

Status Recruiting

Clinical Trial Summary

The purpose of this study is to compare the clinical and functional outcomes of patients with mild to moderate arthroscopically confirmed osteoarthritis between the following two groups: 1. Partial fat pad harvest with Adipose-Derived Stem Cell (ADSC) transplantation with standard arthroscopic treatment consisting of: partial meniscectomy, cartilage stabilization, loose body removal and selective synovectomy. 2. Standard arthroscopic treatment (above) without cell transplant.

Clinical Trial Description

Adipose-derived stem cells (ADSC) may be beneficial to patients with OA because they may differentiate into chondrocytes, promote endogenous tissue repair, and have potent anti-inflammatory properties. Early studies show promising clinical results using ADSCs to treat patients with osteoarthritis, but no clinical trials have been completed comparing cellular therapy to standard arthroscopic treatment. The investigators aim to determine whether ADSC transplantation as adjuvant therapy in patients with arthroscopic findings of mild to moderate arthritis will result in improved clinical outcomes scores at one and two-year follow-up compared to standard arthroscopic treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03014401
Study type	Interventional
Source	University of Colorado, Denver
Contact	Veronica Butler
Phone	(720)872-0112
Email	dragoo.lab@ucdenver.edu
Status	Recruiting
Phase	N/A
Start date	May 2016
Completion date	December 2025

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04651673` - Prescribed Knee Brace Treatments for Osteoarthritis of the Knee (Knee OA)
Completed	`NCT05677399` - Knee Osteoarthritis Treatment With Peloidotherapy and Aquatic Exercise.	N/A
Active, not recruiting	`NCT04043819` - Evaluation of Safety and Exploratory Efficacy of an Autologous Adipose-derived Cell Therapy Product for Treatment of Single Knee Osteoarthritis	Phase 1
Recruiting	`NCT06000410` - A Study to Evaluate the Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee	Phase 3
Completed	`NCT05014542` - Needling Techniques for Knee Osteoarthritis	N/A
Recruiting	`NCT05892133` - Prehabilitation Effect on Function and Patient Satisfaction Following Total Knee Arthroplasty	N/A
Recruiting	`NCT05528965` - Parallel Versus Perpendicular Technique for Genicular Radiofrequency	N/A
Active, not recruiting	`NCT03472300` - Prevalence of Self-disclosed Knee Trouble and Use of Treatments Among Elderly Individuals
Active, not recruiting	`NCT02003976` - A Randomized Trial Comparing High Tibial Osteotomy Plus Non-Surgical Treatment and Non-Surgical Treatment Alone	N/A
Active, not recruiting	`NCT04017533` - Stability of Uncemented Medially Stabilized TKA	N/A
Completed	`NCT04779164` - The Relation Between Abdominal Obesity, Type 2 Diabetes Mellitus and Knee Osteoarthritis	N/A
Recruiting	`NCT04006314` - Platelet Rich Plasma and Neural Prolotherapy Injections in Treating Knee Osteoarthritis	N/A
Recruiting	`NCT05423587` - Genicular Artery Embolisation for Knee Osteoarthritis II	N/A
Enrolling by invitation	`NCT04145401` - Post Market Clinical Follow-Up Study- EVOLUTION® Revision CCK
Active, not recruiting	`NCT03781843` - Effects of Genicular Nerve Block in Knee Osteoarthritis	N/A
Recruiting	`NCT05974501` - Pre vs Post Block in Total Knee Arthroplasty (TKA)	Phase 4
Completed	`NCT05324163` - Evaluate Efficacy and Safety of X0002 in Treatment of Knee Osteoarthritis	Phase 3
Completed	`NCT05529914` - Effects of Myofascial Release and Neuromuscular Training for Pes Anserine Syndrome Associated With Knee Osteoarthritis	N/A
Recruiting	`NCT05693493` - Can Proprioceptive Knee Brace Improve Functional Outcome Following TKA?	N/A
Not yet recruiting	`NCT05510648` - Evaluation of the Effect of High-intensity Laser Therapy in Knee Osteoarthritis	N/A