Knee Osteoarthritis Clinical Trial
Official title:
Mixed Methods Study to Evaluate Pain, Function, Postural Stabilisation, and Fear of Movement Following a Lower Limb Exercise Programme for Knee Osteoarthritis
Osteoarthritis (OA) is a condition that causes cartilage loss, bony remodeling, joint stiffness and generalized muscle weakness. 90% of OA presentation has been reported within the leg; with 44% affecting the knee joint. Knee OA is expected to increase by 50% over the next twenty years due to an ageing population, obesity, and societal trends such as lack of activity. Only 13% of knee OA sufferers reach the recommended levels of exercise therefore an understanding of how psychological and functional relationships effect exercise engagement, which in turn would provide a more comprehensive rehabilitation programme for patients with knee OA. The aim of this study is to investigate exercise in knee OA and it it's correlation with fear of movement, using a mixed methods approach. Quantitative methodology will investigate lower limb exercises for pain and function and fear of movement. The desired outcome of the study will show that a reduction in pain with patient specific exercise will also reduce the fear of movement and allow patients to self-manage their symptoms without fear. Other quantitative factors such as intensity of exercise and postural stabilization using the Y balance test will also be utilized to review the functional relationship of muscle strength and balance to kinesiophobia. A semi-structured interview will be completed at the end of the course of treatment to highlight what patients think about exercise as an intervention. Participants aged forty-five and above with specific clinical symptoms will be invited into the study and will be asked to attend eight exercise sessions within a class environment, which will last for 1 hour within the Physiotherapy Department.
Exercise is recommended for the treatment for knee osteoarthritis (OA) with muscle strength
and aerobic exercise improving physical function. There is evidence supporting quadriceps
strength for patients with painful knee OA; positive effects on pain; and general fitness.
Research reviews by suggest exercise as an important aspect of rehabilitation in knee OA.
However, there is very limited evidence to what type of exercises actually decrease pain and
improve activity.
Despite positive evidence regarding exercise, highlighted major issues within the United
Kingdom with only 5% of people with knee OA achieving the recommended level of activity and
57% of the population not completing regular exercise. 1% to 4% of total healthcare costs
account for physical inactivity which cost 8.3 billion in 2009.
An essential factor of physical inactivity is exercise behaviour. Fear of movement is an
important aspect of knee OA. Disability is present due to the individual's fear of physical
movements that would cause pain. Evidence links fear of movement with knee OA and the role
of exercise in the management of knee OA. Patients with OA experience pain during activity,
which leads to an expectation that further activity, will cause greater pain therefore
increasing muscle weakness. It has been indicated that individuals could have negative
attitudes and beliefs about their knee problems, which could cause a barrier to treatment,
with socioeconomic, personality and environmental factors being as important as the physical
characteristics. Other factors such as balance issues and laxity of the knee have been
associated with activity limitations. However, in a systematic review found weak evidence to
support pain, distress, and avoidance of activity in participants with knee OA.
Understanding individual exercise behaviours and habits is essential to improve exercise
adherence. Non-compliance is common within physiotherapy with patients unwilling to
accommodate exercises within everyday life. Reasons for this may include type of exercises,
dosage, and underlying beliefs from the clinicians towards exercise as well as external
factors. Incorrect prescription of exercises can lead to increased pain, decreased function
and decreased exercise adherence. This could cause fear of movement whilst completing
exercise. It has been concluded that in OA there is limited evidence that interventions can
improve exercise adherence. Therefore, an understanding of non-adherence and the effects of
kinesiophobia is essential to further develop exercise programmes for patients with OA.
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Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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