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Knee Osteoarthritis clinical trials

View clinical trials related to Knee Osteoarthritis.

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NCT ID: NCT06087562 Active, not recruiting - Knee Osteoarthritis Clinical Trials

iPACK Block for Total Knee Arthroplasty

Start date: June 16, 2020
Phase: Phase 4
Study type: Interventional

This randomized, double-blinded, placebo-controlled trial seeks to evaluate the efficacy of the rehabilitation process of the Interspace between the Popliteal Artery and Capsule of the Posterior Knee (iPACK) block in total knee arthroplasty.

NCT ID: NCT06063356 Active, not recruiting - Knee Osteoarthritis Clinical Trials

Effects of Dextrose Prolotherapy in Patients With Knee Osteoarthritis

Start date: August 15, 2023
Phase: N/A
Study type: Interventional

In this prospective, randomized, controlled, single-blinded study, we aimed to evaluate the effects of Dextrose Prolotherapy injections in patients with chronic knee osteoarthritis.

NCT ID: NCT06042322 Active, not recruiting - Knee Osteoarthritis Clinical Trials

Retrospective Analysis of Pain After Nerve Block in Surgical Patients

Start date: January 1, 2017
Phase:
Study type: Observational

This is a retrospective study looking at patients who received a nerve block for surgery and assessing pain after the nerve block resolves, with or without an educational intervention, over two periods of time.

NCT ID: NCT05925517 Active, not recruiting - Knee Osteoarthritis Clinical Trials

The Effect of Graded Motor Imagery on Pain and Function in Individuals With Knee Osteoarthritis

Start date: July 15, 2023
Phase: N/A
Study type: Interventional

The aim of this study is to investigate whether Graded Motor Imagery (GMI) application is as effective as Transcutaneous Electrical Nerve Stimulation (TENS) in individuals with knee osteoarthritis (OA). The objectives are to improve range of motion (ROM) and muscle strength, reduce pain and stiffness, increase pain pressure threshold, and enhance function and physical performance through GMI application.

NCT ID: NCT05920590 Active, not recruiting - Knee Osteoarthritis Clinical Trials

The Effect of Proprioceptive Neuromuscular Facilitation and Tendon Vibration After Total Knee Arthroplasty

Start date: April 1, 2023
Phase: N/A
Study type: Interventional

Knee osteoarthritis is a degenerative joint disease characterized by destruction and progressive loss of articular cartilage. In an advanced stage of the disease, the patient undergoes a total replacement of the knee joint with an artificial joint (total arthroplasty). The aim of this clinical study is to investigate the effect of combining a therapeutic exercise program based on Proprioceptive Neuromuscular Facilitation (PNF) and tendon vibration in older adult patients after total knee arthroplasty (TKA). Ninety (90) adults over 65 years of age who will undergo TKA due to knee osteoarthritis will be divided into three groups of 30 people each (two intervention and one control). The participants of the first group will follow a therapeutic exercise protocol based on the PNF technique for six weeks. The participants of the second intervention group will follow the same therapeutic exercise program based on PNF and at the same time tendon vibration will be applied to the Achilles tendon for the same period. Finally, the participants of the third group (control group) will follow the conventional physical therapy postoperative treatment. The subjective perception of pain with the Numeric Pain Rating Scale (NPRS), Active Range of Motion (AROM) of knee flexion with a goniometer, functional ability with the Knee Injury Outcome Questionnaire and osteoarthritis (Knee Injury and Osteoarthritis Outcome Score, KOOS), quality of life with the Western Ontario and McMaster Universities Arthritis Index (WOMAC), balance confidence with the balance confidence (CONFbal) scale, dynamic balance with the Time Up and Go (TUG) tests and Berg Balance Scale (BBS), displacement of the center of mass by static posturography, and knee proprioception by calculating joint position sense with an isokinetic dynamometer will be assessed at the beginning of the intervention , at week 3, week 6 and six months after the end of the intervention. For the statistical analysis of the results, a two-factor analysis of variance with repeated measurements will be applied, while the statistical significance index will be set at p < .05.

NCT ID: NCT05865899 Active, not recruiting - Knee Osteoarthritis Clinical Trials

Impact of High Tibial Osteotomy in Preventing Degenerative Disease Progression in Medial Knee Osteoarthritis.

HTO-IOR
Start date: May 17, 2021
Phase: N/A
Study type: Interventional

High tibial osteotomy (HTO) surgical procedure can lead to clinically significant improvements in the cartilage and in subchondral bone quality, with a slow down of the osteoarthritis (OA) progression. Aim of the project is to: (i) clinically validate a 3D planned HTO surgical approach, through a quantitative grading of OA progression in a prospective randomized case-control clinical trial; (ii) correlate the internal knee loads with the changes assessed in cartilage and subchondral bone status to verify the hypothesis that HTO induced mechanical changes are associated with clinically significant OA improvements; (iii) relate imaging data with cartilage and subchondral bone mechanical properties, in order to classify OA progression in a more sensitive manner and allow a more precise diagnosis of the pathology stage.

NCT ID: NCT05790824 Active, not recruiting - Knee Osteoarthritis Clinical Trials

Benefits of Spa Therapy in Saint-Lary Soulan for Knee Osteoarthritis

LARYTHERM
Start date: May 1, 2023
Phase: N/A
Study type: Interventional

The hypothesis is that the use of spa therapy in Saint-Lary Soulan for knee osteoarthritis treatment would have a therapeutic effect on this pathology. The main objective of this external comparison study is to evaluate the comparative effectiveness at 6 months of spa therapy in the Saint-Lary Soulan spa center on functional disability and pain (MCII: Minimal Clinical Important Improvement) in knee osteoarthritis compared to the control group of the Thermarthrose multicenter randomized clinical trial, receiving standard cares. The patients included in the Larytherm cohort will undergo a three-week spa therapy in Saint-Lary Soulan with a follow-up of 6 months after the end of spa therapy.

NCT ID: NCT05767788 Active, not recruiting - Knee Osteoarthritis Clinical Trials

Mobilization With Movement (MWM) on Knee Osteoarthritis (OA)

Start date: December 10, 2022
Phase: N/A
Study type: Interventional

Movement with mobilization (MWM) is an effective manual therapy to improve pain and function of patients with knee osteoarthritis (OA). However, immediate, and prolonged effects after prolonged MWM period was under-investigated. In this double-blinded randomized control trial, 40 patients are needed. The subjects and assessors will be blinded. Subjects in intervention group will receive MWM twice a week and corresponding home exercise for 6 weeks. Participants in control group will only receive sham treatment with light touch. The effects on knee pain in visual analogue scale (VAS); flexion and extension range of motion (ROM) by goniometer; strength by hand-held dynamometer; function by Timed Up and Go Test (TUG) and 30-second Chair Stand Test; and health-related quality of life (HRQoL) by Knee Injury and Osteoarthritis Outcome Score (KOOS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) just after, 1-month and 3-month after treatment will be compared with baseline. Six-month after treatment, KOOS and WOMAC will be conducted.

NCT ID: NCT05618782 Active, not recruiting - Pain Clinical Trials

Clinical Trial to Evaluate the Efficacy and Safety of LEVI-04 in Patients With Osteoarthritis of the Knee

Start date: October 17, 2022
Phase: Phase 2
Study type: Interventional

This is a phase 2, randomized, double-blind, placebo-controlled trial of multiple doses and multiple administrations of LEVI-04 for the treatment of pain due to osteoarthritis of the knee.

NCT ID: NCT05550428 Active, not recruiting - Knee Osteoarthritis Clinical Trials

The Effects of Pulsed Electromagnetic Field Therapy on Patients With End-stage of Knee Osteoarthritis

Start date: November 1, 2022
Phase: N/A
Study type: Interventional

A double-blinded, randomizepd controlled trial to investigate the treatment effects of pulsed electromagnetic field (PEMF) on end stage of knee osteoarthritis patients with sarcopenia will be carried out. Subjects will be recruited from the Prince of Wales Hospital. Sixty participants age ≥ 60 will be invited to join this trial after informed consent. They will be randomised to any of the 2 groups: intervention group (n=30; PEMF (Quantum Tx) treatment), and control group (n=30; sham treatment with dummy exposure to PEMF). Both group will receive home-based exercise. Baseline measurements include appendicular muscle mass by DXA, bone microarchitecture (XtremeCT II), knee flexion and extension strength by handheld dynamometer, knee flexion and extension range of motion by goniometer, self-reported knee pain (VAS) and function by The Knee Injury and Osteoarthritis Outcome Score (KOOS), International Physical Activity Questionnaire (IPAQ) for assessment of physical activity level, quality of life by SF-36, hand grip test, bioelectrical impedance analysis (BIA)of body composition, postural stability, chair stand test, 30s arm curl test and 6-meter walking test. These measurements will be performed again at middle and end of treatment, 3, 6, and 12 months after commencement of treatment, except DXA, which will not be performed at the midpoint. In addition, blood samples will be taken at baseline, middle, and end of treatment, 3, 6, and 12 months after commencement of treatment, for determing of serum myokines which are reported to be sensitive to PEMF treatment and contribute to myogenesis. The aim of this study is to conduct a double-blinded, randomized controlled trial to investigate the effects of PEMF treatment on muscle gain and pain relief in knee osteoarthritis with sarcopenia elderly in Hong Kong. We hypothesize that PEMF treatment is effective to promote a gain in muscle mass and function and pain relief in knee osteoarthritis with sarcopenia elderlies.