Knee Osteoarthritis Clinical Trial
Official title:
Tai Chi and Physical Therapy for Knee Osteoarthritis
We will conduct a large randomized controlled trial comparing the effectiveness and cost-effectiveness of Tai Chi mind-body exercise and standard-of-care Physical Therapy for Knee Osteoarthritis.
Osteoarthritis (OA) causes pain and long-term disability, and the public health impact will
increase as the population ages. In addition to inconsistent effectiveness, current
treatments such as nonsteroidal anti-inflammatory drugs, knee replacement, and physical
therapy may be expensive, result in serious adverse effects, reduce physical function, and
fail to improve mental well-being. Finding effective treatments to maintain function and
quality of life in OA patients is one of the national priorities identified this year by the
Institute of Medicine.
We propose to conduct the first comparative effectiveness and cost-effectiveness trial of
Tai Chi vs. physical therapy (PT) in a large symptomatic Knee OA population. A single-blind,
randomized, controlled trial of Tai Chi vs. Physical Therapy will be conducted in 180
patients who meet the American College of Rheumatology criteria for Knee OA. Patients will
be randomized to 12 weeks of treatment with Tai Chi (2x/week) or Standard Physical Therapy
(2x/week for 6 weeks, followed by 6 weeks of rigorous supervised home exercise) with 24 and
52 week follow-ups.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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