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Head-dOwn Position for ischEmic Stroke With Middle Cerebral Artery (HOPES) — HOPES  

Ischemic Stroke Clinical Trial

Official title:
Head-dOwn Position for ischEmic Stroke With Middle Cerebral Artery (HOPES): a Prospective, Random, Multi-Center, Pilot Trial

Clinical Trial Summary

The study is designed to explore the efficacy and safety of head-down position in patients with acute ischemic stroke。

Clinical Trial Description

Currently, the guideline recommended re-perfusion such as intravenous thrombolysis and mechanical thrombectomy as the most effective treatment for acute ischemic stroke. However, the two methods are restricted by a strict time window, which greatly limits the number of the patients receiving treatment. The abundant studies have suggested that good collateral circulation can provide compensatory blood supply to save the ischemic penumbra and reduces the infarct volume, which improves the prognosis. How to improve collateral circulation in an efficient and safe way is a clinical challenge. Our recent experiment results of the animal and clinical experiments show that head-down position can significantly increase cerebral perfusion and improve neurological function. Clinically, head-down position is simple and easy to operate, and theoretically may increases brain perfusion and improve collateral circulation. A pilot randomized clinical trial is designed to investigate the effect of head-down position combined with routine rehabilitation in patients with ischemic stroke. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03629652
Study type Interventional
Source General Hospital of Shenyang Military Region
Contact
Status Terminated
Phase N/A
Start date August 6, 2018
Completion date September 30, 2021
View Details
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