Long-term Sacral Nerve Stimulation for Irritable Bowel Syndrome.

Status Completed

Clinical Trial Summary

A recent randomised, controlled, crossover study has shown that sacral nerve stimulation (SNS) significantly reduces symptoms and improves quality of life of highly selected patients with irritable bowel syndrome (IBS). Relief of IBS symptoms during SNS is associated with consistent changes in rectal sensitivity and biomechanical wall properties.

The aim of the present study is to evaluate long-term efficacy of sacral nerve stimulation on symptoms and quality of life in patients with IBS in a randomised, placebo-controlled, crossover study.

Clinical Trial Description

Twenty two patients with IBS-D or IBS-M according to the ROME III criteria, will be enrolled by invitation in the study.

Having meet inclusion criteria, the patients are first set subsensory for 4 weeks and then randomised to receive either OFF-subsensory or subsensory-OFF stimulation in a 4+4-week period.

During the PNE test the effect of the stimulation is evaluated by specific IBS symptom and quality of life questionnaires (GSRS-IBS and IBS-IS) and bowel habit diaries. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02294760
Study type	Interventional
Source	University of Aarhus
Contact
Status	Completed
Phase	N/A
Start date	November 2014
Completion date	December 2016

View Details

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