Iron Deficiency Anemia Clinical Trial
Official title:
Comparison of Ferrous Sulfate, Polymaltose Complex and Iron-zinc in Iron Deficiency Anemia
The aim of the present study was to compare the effectiveness of the different oral iron preparations in children with IDA.
Iron deficiency (ID) is the most common cause of the anemia throughout the world, with
almost half of the population in developing countries suffering from ID. Children with iron
deficiency anemia (IDA) may have functional consequences including impaired motor and
physical growth. In the case of IDA, the underlying cause should be identified and treated.
Iron supplementation remains an important strategy for the prevention and treatment of IDA
and can produce substantial improvements in the functional performance of iron deficient
individuals.
The iron-containing preparations available on the market vary widely in dosage, salt, and
chemical state of iron (ferrous or ferric form). Current treatment strategy for IDA involves
the oral use of Fe2+ salts (Fe SO4) and Fe3+ polymaltose complexes (FeOH3). Most of these
preparations vary in their bioavailability, efficacy, side effects, and cost. Animal studies
have not shown any significant difference in their oral bioavailability. However, in
clinical practice, bivalent iron salts such as ferrous sulfate (Fe-S), ferrous gluconate,
and ferrous fumarate are more widely used and are preferred over ferric iron preparations.
Fe-S preparations usually present good bioavailability (between 10 and 15 %), while
bioavailability of ferric iron preparations is 3 to 4 times less than that of conventional
Fe-S. This is due to the extremely poor solubility of ferric iron in alkaline media and the
fact that ferric iron needs to be transformed into ferrous iron before being absorbed. For
this reason, among ferrous preparations, Fe-S remains the established and the standard
treatment of ID due to its acceptable tolerability, high effectiveness, and low cost. The
aim of the present study was to compare the effectiveness of the different oral iron
preparations in children with IDA.
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Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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