Influenza Clinical Trial
Official title:
Protective Mechanisms Against a Pandemic Respiratory Virus: B-Cell, T-cell, and General Immune Response to Seasonal Influenza Vaccine. Year 3, 2011
This study will investigate markers, mechanisms and define general predictors for immunological health by comparing influenza vaccine responses in monozygotic and dizygotic twins.
The investigators plan to study the response to influenza vaccines much more broadly and
deeply across different age groups and with different vaccine formulations and to probe the
influence of genetics on these responses using monozygotic and dizygotic twins. On an
investigational basis, investigators plan to compare various immunological responses,
identify age-specific biomarkers or clusters of markers, quantify the frequency of
influenza-specific T-cells pre- and post-vaccination, and determine the effective breadth of
T-cell repertoire to an influenza vaccine within an individual as a function of age and to
what degree this is genetically determined.
Twin Groups B-E will receive a single administration of the 2011-2012 formulation of seasonal
trivalent inactivated influenza vaccine (TIV). Group F, elderly monozygotic twin
participants, will be randomly assigned to receive a single dose of inactivated vaccine,
either the usual dose or the High-Dose TIV. Blood samples to conduct the assays described
will be taken at pre-immunization, Days 7-10 and 28 post-immunization. The number of
individual participants, not the number of twin pairs is being reported in all the modules.
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