Inflammation Clinical Trial
Official title:
A Cross-sectional Study Investigating the Levels and Effects of Low-grade Inflammation in Diabetic Retinopathy of Type 1 Diabetes
There is much evidence that localized low grade inflammatory processes may contribute to the
microvascular complications of type 1 and type 2 diabetes mellitus including
sight-threatening diabetic retinopathy. Some biomarkers for inflammation have been found to
be elevated in diabetes patients and correlations between those biomarkers and the severity
of diabetic complications have been found in the last years. The relation between this low
grade inflammation and the microvascular changes observed in diabetic retinopathy is,
however, not well characterized.
In the present study patients with different stages of non-proliferative diabetic
retinopathy will be included. Several markers of inflammation will be measured from blood
samples. These markers will be related to vascular factors including flicker-induced
vasodilatation as a marker of endothelial dysfunction and perifoveal leukocyte velocity and
density as measured with the blue field entoptic phenomenon. In addition, the ophthalmologic
status of the patients will be assessed according to the Modified Airlie House
classification.
A multiple regression model will be employed to study the association between the different
methods.
n/a
Observational Model: Cohort, Time Perspective: Cross-Sectional
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